Kholmirzo Kholmurodov

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Interactions of calcium (Ca2+) and zinc (Zn2+) cations with biomimetic membranes made of dipalmitoylphosphatidylcholine (DPPC) were studied by small angle neutron diffraction (SAND). Experiments show that the structure of these lipid bilayers is differentially affected by the two divalent cations. Initially, both Ca2+ and Zn2+ cause DPPC bilayers to(More)
The interaction of the 11-cis-retinal chromophore with the surrounding amino acid residues in the chromophore center of the rhodopsin protein has been investigated for the Е181К mutant form using molecular dynamics simulation. A comparative analysis of the arrangement of the amino acid residues in the chromophore center has been performed for both wild(More)
An analysis of the molecular dynamics ( D) of the biphenyl molecular complex in an acidic solution has been performed. The aim of this work is to study the influence of the electrostatic (Coulomb) forces on the dynamical and structural behavior of the biphenyl molecules interacting with the NO3 solvent. The temperature and energy characteristics and the(More)
The aim of this work is to estimate the value of the electric field (potentials) for the system of valinomycin + К and Na ions based on a molecular dynamics (MD) study. An analysis has been performed of the interaction processes for the system of valinomycin + К(Na) ion in water solvent. It is obtained that capturing a К(Na) ion in the valinomycin cavity is(More)
Rhodopsin is a light-driven G-protein-coupled receptor that mediates signal transduction in eyes. Internal water molecules mediate activation of the receptor in a rhodopsin cascade reaction and contribute to conformational stability of the receptor. However, it remains unclear how internal water molecules exchange between the bulk and protein inside, in(More)
A comparative molecular dynamics (MD) simulation study was performed on the p53 oncoprotein to investigate the effect of the Arg273His (R273H) mutation on the p53DNA Binding Domain (DBD). The two p53 dimer structures of the wild-type and mutant Arg273His (R273H) were simulated with the same thermodynamic and environmental parameters. The obtained results(More)
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