Khoa Van Pham

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The Genome in a Bottle Consortium, hosted by the National Institute of Standards and Technology (NIST) is creating reference materials and data for human genome sequencing, as well as methods for genome comparison and benchmarking. Here, we describe a large, diverse set of sequencing data for seven human genomes; five are current or candidate NIST Reference(More)
Chronic nerve compression (CNC) injury initiates a series of pathological changes within the peripheral nerve at the site of injury. However, to date, little work has been performed to explore neuronal cell body responses to CNC injury. Here we show a preferential upregulation of growth-associated protein-43 (GAP-43) and enhanced Fluoro Ruby uptake by the(More)
KChIP3 (potassium channel interacting protein 3) is a calcium-binding protein that binds at the N terminus of the Kv4 voltage-gated potassium channel through interactions at two contact sites and has been shown to regulate potassium current gating kinetics as well as channel trafficking in cardiac and neuronal cells. Using fluorescence spectroscopy,(More)
BACKGROUND Detachment of a tendon from its osseous insertion, as can be the case with severe rotator cuff injuries, leads to atrophy of and increased fat in the corresponding muscle. We sought to validate a rotator cuff injury model in the rabbit and to test the hypothesis that tenotomy of a rotator cuff tendon would consistently create muscle atrophy and(More)
Limited work has been done to investigate the molecular mechanisms behind the process of demyelination and remyelination that occurs in response to chronic nerve compression (CNC) injury. In the present study, we investigated the expression of the transcription factors krox-20 and c-jun, positive and negative regulators of myelination, respectively. A(More)
PURPOSE Smoking is a risk factor in the development of a variety of neuroretinal diseases. Therefore, we have investigated the effects of hydroquinone (HQ), a toxicant that is present in high concentrations in cigarette smoke, on a human retinal Müller cell line (MIO-M1). METHODS MIO-M1 cells were treated for 24h with four different concentrations of HQ(More)
Compression neuropathies are highly prevalent, debilitating conditions with variable functional recovery following surgical decompression. Due to the limited amount of human nerve tissue available for analysis, a number of animal models have been created to help investigators understand the molecular and cellular pathogenesis of chronic nerve compression(More)
Memristors were mathematically found by L. O. Chua in 1971 and experimentally demonstrated by HP researchers in 2008 [1], [2]. Since then, memristors have been considered suitable for neuromorphic circuits and systems, because they have some similarities with brain’s neuronal systems [3], [4], [5]. Memristors are possibly 3-dimensioanl, parallel, analog,(More)
Nanoscale memristors can be used as synapses in brain-mimicking neuromorphic systems. Here, the fine tuning of memristor conductance is important in controlling the synapse weights precisely, because the coarse tuning of memristor synapses can cause a significant error in neuromorphic processing. In this paper, we propose a new Pulse Amplitude Modulation(More)
Introduction: Until recently, chronic nerve compression (CNC) injuries have been relatively understudied. Recent studies have shown that CNC injury induces Schwann cell proliferation and apoptosis with no morphologic evidence of axonal injury (1,2). Moreover, axons within the zone of injury undergo a sprouting response that is readily apparent by two weeks(More)