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Little is known about the relative role of cAMP-dependent protein kinase (cAPK) and guanine exchange factor directly activated by cAMP (Epac) as mediators of cAMP action. We tested cAMP analogs for ability to selectively activate Epac1 or cAPK and discriminate between the binding sites of Epac and of cAPKI and cAPKII. We found that commonly used cAMP(More)
The cAMP-dependent protein kinase (PKA I and II) and the cAMP-stimulated GDP exchange factors (Epac1 and -2) are major cAMP effectors. The cAMP affinity of the PKA holoenzyme has not been determined previously. We found that cAMP bound to PKA I with a K(d) value (2.9 microM) similar to that of Epac1. In contrast, the free regulatory subunit of PKA type I(More)
Computing workloads often contain a mix of interactive, latency-sensitive foreground applications and recurring background computations. To guarantee responsiveness, interactive and batch applications are often run on disjoint sets of resources, but this incurs additional energy, power, and capital costs. In this paper, we evaluate the potential of hardware(More)
The first portion of the BABAR experiment Level 1 Drift Chamber Trigger pipeline is the Track Segment Finder (TSF). Using a novel method incorporating both occupancy and drift-time information, the TSF system continually searches for segments in the supercells of the full 7104-wire Drift Chamber hit image at 3.7 MHz. The TSF was constructed to operate in a(More)
BACKGROUND The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of full-length RIα and a truncated RIα(92-381) that contains(More)
The BABAR detector at PEP-II will operate in a high-luminosity e + e ? collider environment near the (4S) resonance with the primary goal of studying CP violation in the B meson system. In this environment, typical physics events of interest involve multiple charged particles. These events are identified by counting these tracks in a fast first level (Level(More)
The environment of the high-luminosity PEP-II machine poses unique design challenges for the trigger system of the BABAR detector. These led to the adoption of a real-time parallel pipelined architecture for the trigger electronics which departs significantly from previous implementations at conventional · experiments. One challenge for the trigger designer(More)
We present novel methods for eeciently sharing the content produced during collab-orative interactions among internetworked users. We introduce the concept of semantic multicast to implement a large-scale shared interaction infrastructure providing mechanisms for collecting, indexing, and disseminating the information produced in collaborative sessions.(More)
The Transverse Momentum Discriminator Module (PTDM) is one of the three main modules used in the Level 1 Charged Particle Trigger System of the BABAR Detector at PEP-II. It provides trigger decisions for charged particles with a transverse momentum, P t , greater than a configurable threshold. The transverse momentum discrimination algorithm works by(More)
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