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An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
Remyelination is the generation of new myelin sheaths after injury facilitated by processes of differentiating oligodendrocyte precursor cells (OPCs). Although this repair phenomenon occurs inExpand
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Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy
For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce demyelination, without a clear understanding of its mechanisms. LPC is an endogenous lysophospholipid so it may causeExpand
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The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis
The central nervous system (CNS) is immune privileged with access to leukocytes being limited. In several neurological diseases, however, infiltration of immune cells from the periphery into the CNSExpand
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Immunosenescence of microglia and macrophages: impact on the ageing central nervous system.
Ageing of the central nervous system results in a loss of both grey and white matter, leading to cognitive decline. Additional injury to both the grey and white matter is documented in manyExpand
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Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.
The migration of leukocytes into the CNS drives the neuropathology of multiple sclerosis (MS). This penetration likely utilizes energy resources that remain to be defined. Using the experimentalExpand
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Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue. Microglia and infiltrating macrophages are thought to orchestrate theExpand
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Olfactory ensheathing cells of hamsters, rabbits, monkeys, and mice express α-smooth muscle actin
Olfactory ensheathing cells (OECs) are the chief glial population of the mammalian olfactory nervous system, residing in the olfactory mucosa and at the surface of the olfactory bulb. We investigatedExpand
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The Role of Astrocytes in Remyelination
Remyelination is the regeneration of myelin sheaths following demyelination. This regenerative process is critical for the re-establishment of axonal conduction velocity and metabolic support to theExpand
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Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity
ABSTRACT The dismal prognosis of glioblastoma is attributed in part to the existence of stem-like brain tumor-initiating cells (BTICs) that are highly radio- and chemo-resistant. New approaches suchExpand
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Regenerative Capacity of Macrophages for Remyelination
White matter injury, consisting of loss of axons, myelin, and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. RemyelinationExpand
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