Khalid Raza

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The main goal of Systems Biology research is to reconstruct biological networks for its topological analysis so that reconstructed networks can be used for the identification of various kinds of disease. The availability of high-throughput data generated by microarray experiments fuelled researchers to use whole-genome gene expression profiles to understand(More)
Genetic Regulatory Networks (GRNs) plays a vital role in the understanding of complex biological processes. Modeling GRNs is significantly important in order to reveal fundamental cellular processes, examine gene functions and understanding their complex relationships. Understanding the interactions between genes gives rise to develop better method for drug(More)
The high-throughput data generated by microarray experiments provides complete set of genes being expressed in a given cell or in an organism under particular conditions. The analysis of these enormous data has opened a new dimension for the researchers. In this paper we describe a novel algorithm to microarray data analysis focusing on the identification(More)
— Reconstruction of gene regulatory networks or 'reverse-engineering' is a process of identifying gene interaction networks from experimental microarray gene expression profile through computation techniques. In this paper, we tried to reconstruct cancer-specific gene regulatory network using information theoretic approach-mutual information. The considered(More)
Inferring gene interaction network from gene expression data is an important task in systems biology research. The gene interaction network, especially key interactions, plays an important role in identifying biomarkers for disease that further helps in drug design. Ant colony optimization is an optimization algorithm based on natural evolution and has been(More)
Prostate cancer is among the most common cancer in males and its heterogeneity is well known. The genomic level changes can be detected in gene expression data and those changes may serve as standard model for any random cancer data for class prediction. Various techniques were implied on prostate cancer data set in order to accurately predict cancer class(More)
Systems biology is an emerging interdisciplinary area of research that focuses on study of complex interactions in a biological system, such as gene regulatory networks. The discovery of gene regulatory networks leads to a wide range of applications, such as pathways related to a disease that can unveil in what way the disease acts and provide novel(More)