Khalid Mahmood

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Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal 5'-phosphate-dependent enzyme glutamic acid decarboxylase (GAD65 and GAD67). GAD67 is constitutively active and is responsible for basal GABA production. In contrast, GAD65, an autoantigen in type I diabetes, is transiently activated in response to the demand for extra GABA in(More)
Biotic systems face immense environmental hazards such as accumulation of heavy metals, particularly in agricultural ecosystems that might cause deterioration of yield and quality of crops. In this study, we evaluated the role of silicon (Si) in alleviating the heavy metal (Cd) stress tolerance in cotton by analyzing the induced Physio-chemical changes.(More)
Purpose – This paper aims to survey the web sites of the academic libraries of the Association of Research Libraries (USA) regarding the adoption of Web 2.0 technologies. Design/methodology/approach – The websites of 100 member academic libraries of the Association of Research Libraries (USA) were surveyed. Findings – All libraries were found to be using(More)
MOTIVATION The caspase family of cysteine proteases play essential roles in key biological processes such as programmed cell death, differentiation, proliferation, necrosis and inflammation. The complete repertoire of caspase substrates remains to be fully characterized. Accordingly, systematic computational screening studies of caspase substrate cleavage(More)
Purpose – The aim of this study was to explore the pattern and extent of the adoption of Web 2.0 technologies by Pakistani librarians. Design/methodology/approach – A survey was conducted using web-based surveying software (SurveyMonkey) and Pakistan based LIS e-mail discussion groups. Professional librarians serving in all types of libraries participated(More)
Over 3% of human proteins contain single amino acid repeats (repeat-containing proteins, RCPs). Many repeats (homopeptides) localize to important proteins involved in transcription, and the expansion of certain repeats, in particular poly-Q and poly-A tracts, can also lead to the development of neurological diseases. Previous studies have suggested that the(More)
Broadly, computational approaches for ortholog assignment is a three steps process: (i) identify all putative homologs between the genomes, (ii) identify gene anchors and (iii) link anchors to identify best gene matches given their order and context. In this article, we engineer two methods to improve two important aspects of this pipeline [specifically(More)
BACKGROUND We report our experience with the minimally invasive supraorbital approach to aneurysms of the ipsilateral anterior cerebral circulation. METHODS A prospective review of all patients who underwent operations to clip aneurysms in Newcastle between 1993 and 2002. RESULTS Fifty-six aneurysms were clipped via minicraniotomy in 47 patients. Six(More)
We have used genome-wide genotyping to identify an overlapping homozygosity-by-descent locus on chromosome 9q34.3 (MRT15) in four consanguineous families affected by nonsyndromic autosomal-recessive intellectual disability (NS-ARID) and one in which the patients show additional clinical features. Four of the families are from Pakistan, and one is from Iran.(More)
Telecare medicine information system (TMIS) offers the patients convenient and expedite healthcare services remotely anywhere. Patient security and privacy has emerged as key issues during remote access because of underlying open architecture. An authentication scheme can verify patient’s as well as TMIS server’s legitimacy during remote healthcare(More)