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BACKGROUND Patients with chronic asthma have thicker intrapulmonary airways measured on high resolution computed tomography (HRCT). We determined whether the presence of lower airway bacteria was associated with increased airway wall thickness. METHODS In 56 patients with stable severe asthma, sputum specimens obtained either spontaneously or after(More)
A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. 7 Hovstadius B, A ˚ strand B, Persson U, et al. Acquisition cost of dispensed drugs in individuals with multiple medications – a register-based study in Sweden. Patients with chronic obstructive pulmonary disease (COPD) often suffer from acute(More)
Pseudomonas aeruginosa is a common chronic pulmonary infection in cystic fibrosis (CF). It is associated with poor outcomes and new detection should prompt an early eradication attempt [1–3]. Strict segregation and eradication policies have led to a declining prevalence of chronic P. aeruginosa infection, with only 30% of CF adolescents having chronic(More)
Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain reaction (PCR) assay for the detection of the causative microbe in culture-proven and culture-negative cases(More)
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