Khalid Alshafi

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Injury by contaminated sharp instruments and needles constitutes a major occupational hazard for healthcare workers. In a confidential survey at a district general hospital, 300 healthcare professionals were asked about their personal experience of needle-stick injury and their attitudes to reporting. 279 individuals responded, of whom 38% had experienced(More)
BACKGROUND Patients with chronic asthma have thicker intrapulmonary airways measured on high resolution computed tomography (HRCT). We determined whether the presence of lower airway bacteria was associated with increased airway wall thickness. METHODS In 56 patients with stable severe asthma, sputum specimens obtained either spontaneously or after(More)
Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain reaction (PCR) assay for the detection of the causative microbe in culture-proven and culture-negative cases(More)
the National Cancer Institute for the OCT technology development. The funding sources for this study played no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation of the manuscript. The funding sources did not review the manuscript. S. Lam had full access to all of the(More)
Non-tuberculous mycobacterium (NTM) account for 13% of cystic fibrosis (CF)-related respiratory infections and present a major therapeutic challenge. There is increasing evidence to suggest an adverse prognostic significance of NTM, particularly for Mycobacterium abscessus. A recent large retrospective study of 1216 patients with CF found that growths of(More)
INTRODUCTION The prevalence of MRSA in patients with CF is increasing. There is no consensus as to the optimum treatment. METHOD An observational cohort study of all patients with MRSA positive sputum, 2007-2012. All eradication attempts with subsequent culture results were reviewed. Single vs dual antibiotic regimens were compared for both new and(More)
As antibiotic resistance increases, there is a need for new therapies to treat infection, particularly in cystic fibrosis (CF), where Pseudomonas aeruginosa is a ubiquitous pathogen associated with increased morbidity and mortality. Bacteriophages are an attractive alternative treatment, as they are specific to the target bacteria and have no documented(More)