The negative relation between metabolism and life span is a fundamental gerontological discovery well documented in a variety of ontogenetic and phylogenetic models. But how the long-lived species and populations sustain lower metabolic rate and, in more general terms, what is the efficient way to decline the metabolism? The suggested ‘pull and push back’… (More)
Understanding the main factors that determine variation in species longevity may provide a clue into the leading mechanisms of aging and—what is even more important—outline the key targets for longevity-promoting interventions. Comparative studies on longevity in mammals revealed numerous variables that correlate with maximum lifespan (MLS). However,… (More)
Mitochondria are the only organelles in the animal cells that have their own genome. Due to a key role in energy production, generation of damaging factors (ROS, heat), and apoptosis, mitochondria and mtDNA in particular have long been considered one of the major players in the mechanisms of aging, longevity and age-related diseases. The rapidly increasing… (More)
Introduction: Circadian rhythms are genetically programmed traits coordinating behavior and metabolic responses with daily repeating environmental challenges, primarily with the solar day. Aging and circadian rhythms are interrelated: aging can modify the circadian rhythms, whereas age-changes of the rhythms contribute to the declined adaptability in aging.
Many mutations that extend the lifespan of the lower organisms such as C. elegans and Drosophila, are associated with signaling or apoptotic pathways. Recently, such a possibility was shown in mammals: p66ShcA-deficient mice were more resistant to oxidative stress and lived longer than the wild-type animals [Migliaccio, E., Giorgio, M., Mele, S., Pelicci,… (More)