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Huntington's disease (HD) is an autosomal-dominant neurological disorder caused by expanded CAG repeats in the Huntingtin (Htt) gene, but it is not known how this mutation causes neurodegeneration. Herein, we found that dysfunction of upstream binding factor-1 (UBF-1) is linked to reduced ribosomal DNA (rDNA) transcription in HD. We identified that UBF1… (More)
We report HLA-C*02:02:09 as a novel allele with a transition C->T at position 354.
We report a novel allele HLA-DQB1*06:49 with a G→T transversion, most closely resembling HLA-DQB1*06:02:01.
The new HLA-B*41:45N allele differs from B*41:02 by insertion of 21 nucleotides in exon 2.
The new DQB1*03:02:05 differs from DQB1*03:02:01 by two nucleotide exchanges in exon 2.
We report the new HLA-A*11:192 allele differing from A*11:01 by one nucleotide in exon 2.
We report the new HLA-DRB1*14:99 allele differing from DRB1*14:01:01 by one nucleotide in exon 2.
The new allele HLA-B*52:23 differs from B*52:01:01 at position 208 in exon 2.
Copper accumulation and phosphatase activities of three Aspergillus species resistant to copper were compared to three copper-sensitive Rhizopus species. High level of acid phosphatases and decreased Cu2+-uptake were found with resistant in contrast to sensitive strains. The presence of copper(II) ions in the medium increased the production of acid… (More)