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The role of nitric oxide (NO) in the pathophysiology of gram-positive sepsis is uncertain. In inflammatory conditions, high-output NO production is catalyzed by the enzyme inducible nitric oxide synthase (iNOS). The ability of 2 strains of pneumococci, pneumococcal cell wall preparations, and purified pneumococcal capsule (Pnu-Imune 23) to trigger the(More)
Antibiotic choice can alter host inflammation during invasive bacterial infections. Previous studies of gram-negative organisms concluded that antibiotic-mediated release of bacterial cell wall components amplifies inflammation. Less has been reported about antibiotic effect on gram-positive organisms. This study explored the hypothesis that Streptococcus(More)
Pour obtenir Le grade de docteur Formation doctorale Mathématiques et Informatique (InfoMaths) Bu tez, onurlarıyla var olmaya çalı¸san tüm kadınlara adanmı¸stır. Acknowledgements I would like to express my special appreciation and gratitude to my advisor Prof. Jean-François Bouli-caut. I would like to thank you for encouraging my research. After all our(More)
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