Keyvan Karkouti

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BACKGROUND Acute kidney injury (AKI) after cardiac surgery is a major health issue. Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors. METHODS AND RESULTS Data from a multicenter cohort of(More)
OBJECTIVES The purpose of this study was to assess the effects of off-pump coronary bypass surgery (OPCAB) on mortality and morbidity. BACKGROUND Despite its potential for reducing morbidity and mortality, OPCAB's role in clinical practice remains controversial. METHODS A meta-analysis of 37 randomized controlled trials (RCTs) (n = 3,449) and 22(More)
BACKGROUND Preoperative anemia is an important risk factor for perioperative red blood cell transfusions, which are associated with postoperative morbidity and mortality. Whether preoperative anemia also is an independent risk factor for adverse outcomes after cardiac surgery, however, has not been fully elucidated. METHODS AND RESULTS In this multicenter(More)
CONTEXT A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design. OBJECTIVES To develop a predictive index for RRT using preoperative information. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort of 20 131 cardiac(More)
PURPOSE To develop a clinically useful and valid model for predicting difficult laryngoscopic tracheal intubation in patients with seemingly normal airways by adhering to the principles of multivariable model development. METHODS This was an observational study performed at a tertiary-care teaching hospital. Preoperatively, 444 randomly selected patients(More)
BACKGROUND Although the association between massive perioperative blood loss (MBL) and adverse outcomes is well recognized, it is unclear whether MBL is an independent risk factor or, instead, simply a marker for other adverse events or severity of illness. The objective of this cohort study was to quantify the independent association of MBL in cardiac(More)
BACKGROUND The use of normal saline is associated with hyperchloremic metabolic acidosis. In this study, we sought to determine the incidence of acute postoperative hyperchloremia (serum chloride >110 mEq/L) and whether this electrolyte disturbance is associated with an increase in length of hospital stay, morbidity, or 30-day postoperative mortality. (More)
BACKGROUND Cardiac surgery with cardiopulmonary bypass may result in excessive fibrinolysis and platelet (PLT) dysfunction, resulting in impaired hemostasis and excessive blood loss. Prophylactic use of the antifibrinolytic drugs aprotinin and tranexamic acid is thought to prevent these hemostatic defects. Their relative clinical utility and safety in(More)
BACKGROUND The relationship between degree of hemodilution during cardiopulmonary bypass (CPB) and perioperative stroke has not been fully elucidated. The objective of this observational study was to evaluate the relationship between nadir hematocrit during CPB and perioperative stroke while adjusting for variables known to have an association with stroke(More)