Quinocetone, a new quinoxaline 1,4-dioxide derivative used in food-producing animals in China, exerts genotoxic effects on HepG2 cells. It triggers significant cytotoxicity and genotoxicity in vitro, but the detailed mechanism by which quinocetone induces adverse biological effects is not yet known. We analyzed the mechanisms behind quinocetone intoxication… (More)
In this work we use fixed point theorem method to discuss the existence of positive solutions for the impulsive boundary value problem with Caputo fractional derivative c D q t u(t) = f (t, u(t)), a.e. t ∈ [0, 1]; ∆u(t k) = I k (u(t k)), ∆u (t k) = J k (u(t k)), k = 1, 2,. .. , m; au(0) − bu(1) = 0, au (0) − bu (1) = 0, where q ∈ (1, 2) is a real… (More)
To explore the primary stage or site of action of acetamizuril (AZL), a novel triazine anticoccidial compound, the ultrastructural development of Eimeria tenella at different endogenous stages was studied in experimentally infected chickens treated with a single oral dose of 15 mg/kg AZL. As a result of drug action, the differentiations of second-generation… (More)
This paper investigates the existence and multiplicity of positive solutions for a second-order delay p-Laplacian boundary value problem. By using fixed point index theory, some new existence results are established. c 2015 All rights reserved.
To evaluate the antioxidant and immune effects of low molecular yeast β-glucan on mice, three sulfated glucans from Saccharomyces cerevisiae (sGSCs) with different molecular weight (MW) and degrees of sulfation (DS) were prepared. The structures of the sGSCs were analyzed through high performance liquid chromatography-gel permeation chromatography… (More)
The factors that determine the transcription-regulating sequence (TRS) activity of porcine reproductive and respiratory syndrome virus (PRRSV) remain largely unclear. In this study, the effect of mutagenesis of conserved C nucleotides at positions 5 and 6 in the leader TRS (TRS-L) and/or canonical body TRS7 (TRS-B7) on the synthesis of subgenomic (sg) mRNA… (More)
In this work, we discuss the existence of nontrivial solutions for the fractional boundary value problem D α 0+ u = –f (t, u), t ∈ [0, 1], u(0) = u (0) = u (1) = 0. Here α ∈ (2, 3] is a real number, D α 0+ is the standard Riemann-Liouville fractional derivative of order α. By virtue of some inequalities associated with Green's function, without the… (More)
Japanese encephalitis virus (JEV) has a significant impact on public health. An estimated three billion people in 'at-risk’ regions remain unvaccinated and the number of unvaccinated individuals in certain Asian countries is increasing. Consequently, there is an urgent need for the development of novel therapeutic agents against Japanese encephalitis.… (More)