Keyu Zhang

Learn More
Tylvalosin, a new broad-spectrum, third-generation macrolides, may exert a variety of pharmacological activities. Here, we report on its anti-oxidative and anti-inflammatory activity in RAW 264.7 macrophages and mouse treated with lipopolysaccharide (LPS) as well as piglet challenged with porcine reproductive and respiratory syndrome virus (PRRSV).(More)
Cordyceps militaris polysaccharide (CMP) was prepared by water decoction and ethanol precipitation. The fractional CMP40 and CMP50 were extracted from the CMP solution by stepwise precipitation with ethanol at 40% and 50% of working concentration, respectively. The immune-enhancing activities of two polysaccharides were researched. In vitro experiment, the(More)
Quinoxaline-1,4-dioxides, widely used as medicinal feed additives as antibacterial growth promoters, have been shown to exert diverse toxicities. Their toxicities are hypothesized to be closely related to the formation of N-oxide reductive metabolites. 1,4-Bisdesoxyquinocetone and MQCA are important N-oxide reductive metabolites of quinocetone or(More)
Nitromezuril (NZL) is a novel triazine compound that exhibits remarkable anticoccidial activity. However, mutagenicity and genotoxicity of NZL have not been evaluated to date. This study evaluated the potential risks of NZL by testing for bacterial reverse mutation (Ames), mouse sperm abnormality (SA), bone marrow micronucleus (MN) and chromosomal(More)
Quinocetone (QCT) has been widely used as an animal growth promoter in China. However, amounts of available data indicated that QCT probably had potential toxicity. The present study was aimed to investigate the genotoxicity, mitochondrial damage and apoptosis in HepG2 cells for QCT and its metabolites, DQCT and MQCA. QCT has seriously cytotoxic to HepG2(More)
Quinocetone, a new quinoxaline 1,4-dioxide derivative used in food-producing animals in China, exerts genotoxic effects on HepG2 cells. It triggers significant cytotoxicity and genotoxicity in vitro, but the detailed mechanism by which quinocetone induces adverse biological effects is not yet known. We analyzed the mechanisms behind quinocetone intoxication(More)
To evaluate the immune effect of sulfated glucan from saccharomyces cerevisiae (SGSC) on chickens, two experiments were researched. In vitro experiment, the effects of SGSC on chicken splenic lymphocyte proliferation were determined. The results displayed that SGSC could significantly stimulate chicken splenic lymphocyte proliferation. In vivo experiment,(More)
We subjected Sprague-Dawley rats to an acute and 13-week subchronic oral toxicity of arprinocid, a nucleoside analogue used as a coccidiostat, according to toxicological guidelines as part of its safety assessment. In the acute study, arprinocid was administered once by oral gavage to rats at doses ranging from 292.4 to 506.0mg/kgb.w. The calculated LD50(More)
The anticoccidial efficacy of 2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione (nitromezuril, NZL), a novel triazine compound, was evaluated in three different studies under experimental conditions. The anticoccidial efficacy was chiefly evaluated using the anticoccidial index (ACI). The resistance level was determined by calculating(More)