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Neighbor discovery is crucial for both wireless sensor networks and mobile computing applications. The crux of the problem is to achieve energy efficiency, which has been demonstrated to be difficult by prior work. In this paper we propose Hello, a generic flexible protocol for neighbor discovery. With an unrestricted parameter, it serves as a generic(More)
Many wireless applications urgently demand an efficient neighbor discovery protocol to build up bridges connecting user themselves or to some service providers. However, due to intrinsic constraints of wireless devices, e.g., limited energy and error of clock synchronization, there is still absence of effective and efficient neighbor discovery protocols in(More)
The identification of protein-protein interaction sites is a computationally challenging task and important for understanding the biology of protein complexes. There is a rich literature in this field. A broad class of approaches assign to each candidate residue a real-valued score that measures how likely it is that the residue belongs to the interface.(More)
Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines have been employed to improve clinical outcomes for RSV-infected patients. In this paper, we report that(More)
The continual proliferation of mobile devices has stimulated the development of opportunistic encounter-based networking and has spurred a myriad of proximity-based mobile applications. A primary cornerstone of such applications is to discover neighboring devices effectively and efficiently. Despite extensive protocol optimization, current neighbor(More)
Phosphonomethoxy nucleoside analogs of the thymine containing nucleoside reverse transcriptase inhibitors (NRTIs), 3'-azido-2',3'-dideoxythymidine (AZT), 2',3'-didehydro-2',3'-dideoxythymidine (d4T), and 2',3'-dideoxythymidine (ddT), were synthesized. The anti-HIV activity against wild-type and several major nucleoside-resistant strains of HIV-1 was(More)
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing(More)
Large efforts have been made in classifying residues as binding sites in proteins using machine learning methods. The prediction task can be translated into the computational challenge of assigning each residue the label binding site or non-binding site. Observational data comes from various possibly highly correlated sources. It includes the structure of(More)
Cyclic phosphonomethoxy pyrimidine nucleosides that are bioisosteres of the monophosphate metabolites of HIV reverse transcriptase (RT) inhibitors AZT, d4T, and ddC have been synthesized. The RT inhibitory activities of the phosphonates were reduced for both dideoxy (dd) and dideoxydidehydro (d4) analogs compared to the nucleosides.(More)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide (Li and Satomura, 2015). Early diagnosis and treatment are vital for reducing mortality. Currently, biomarkers such as serum alpha fetoprotein (AFP), AFP-L2, and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients (Shi et al., 2016).(More)