Keyin Liu

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Most of the near-infrared (NIR) fluorescent copper ion probes are coordination-based, and the fluorescence enhancement is between 10 and 20 folds. Herein, a novel NIR fluorescent dye named CSCN with excellent photostability and a reaction-based Cu(2+) NIR probe named CSCN-Cu were reported. CSCN exhibited good photostability toward photo irradiation. CSCN-Cu(More)
By blocking the intramolecular twisted internal charge transfer (TICT) process, we designed and sythesized the first TICT-based fluorescent probe for hydrogen sulfide. The new probe exhibits high selectivity, good membrane-permeability and is suitable for visualization of exogenous and endogenous hydrogen sulfide in living cells.
Thiazole orange-modified diarylethene (1) shows weak fluorescence but no photochromism in aqueous solution. When binding with DNA, the fluorescence of 1 is enhanced drastically and the photochromic reactivity is unlocked. This kind of DNA-responsive photoswitchable system can be used for imaging nucleic acids within cells.
A kind of novel hydrogelator based on (-)-menthol, a traditional cooling compound, tailed by an amino acid derivate through an alkyl chain, has been designed and synthesized. The hydrogelator containing an l-lysine can form a stable hydrogel with thixotropic character in a large pH range. An interesting feature is that the viscoelastic character of the(More)
It is important to detect hydrogen peroxide (H2O2) near mitochondrial DNA (mtDNA) because mtDNA is more prone to oxidative attack than nuclear DNA (nDNA). In this study, a mitochondria-targeted fluorescence probe, pep3-NP1, has been designed and synthesized. The probe contains a DNA-binding peptide, a H2O2 fluorescence reporter, and a positively charged red(More)
As a marker for oxidative stress and a second messenger in signal transduction, hydrogen peroxide (H2O2) plays an important role in living systems. It is thus critical to monitor the changes in H2O2 in cells and tissues. Here, we developed a highly sensitive and versatile ratiometric H2O2 fluorescent probe (NP1) based on 1,8-naphthalimide and boric acid(More)
Two large conjugated naphthalimide derivatives with or without three-methane-bridged thiazole orange (TO3; i.e., compounds 1 a and 2 a, respectively) were designed and synthesized. The fluorescence of the naphthalimide group in compound 1 a at λ=532 nm initially decreased and that for the TO3 group at λ=655 nm increased sequentially upon adding Salmon(More)
H2O2 as one of the most important ROS (Reactive Oxygen Species) has more attack activity to biomolecules such as DNA, RNA, protein and enzyme in alkaline environment and leads to a series of disease. However, no attention has been paid to the fluorescent detection of H2O2 in alkaline environment in the past. Herein, we reported the first ratiometric(More)
A series of aluminium alkyl complexes {PhC(NR')(NR'')}AlR(2) (4a-n, R' = 2,6-(i)Pr(2)C(6)H(3), 2,6-Me(2)C(6)H(3); R'' = aryl groups with various ortho-, para- or meta-substituents, tert-butyl; R = methyl, ethyl) bearing non-symmetrically N-substituted benzamidinate ligands were synthesized via the reaction of trialkylaluminium and the corresponding(More)
Photochromism in a diarylethene derivative (1O) can be gated by a host-guest interaction where the thiazole orange groups are bound into the hydrophobic cavity of CB[8] in water. The closed-ring isomer (1C), which cannot be obtained freely in aqueous solution, survives even when the complex is dissociated by displacement from CB[8] by competition with(More)