Kevin Shields

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OBJECTIVE To establish the phenotypic spectrum of KIF5A mutations and to investigate whether KIF5A mutations cause axonal neuropathy associated with hereditary spastic paraplegia (HSP) or typical Charcot-Marie-Tooth disease type 2 (CMT2). METHODS KIF5A sequencing of the motor-domain coding exons was performed in 186 patients with the clinical diagnosis of(More)
Migraine is a common, debilitating condition affecting up to 15% of the population. The ventroposteromedial nucleus of the thalamus relays trigeminal sensory input to the primary somatosensory cortex. In vivo electrophysiological recordings were made from the cell bodies of thalamocortical relay neurons in rats. We investigated whether microiontophoretic(More)
Successful retrieval of images by shape feature is likely to be achieved only if we can mirror human similarity judgements. Following Biederman’s theory of recognition-by-components, we postulate that shape analysis for retrieval should characterize an image by identifying properties such as collinearity, shape similarity and proximity in component(More)
Triptans, serotonin 5-HT(1B/1D), receptor agonists, which are so effective in acute migraine, are considered to act directly on the trigeminovascular system. Using an in vivo model of trigeminovascular nociception, we report a potentially novel action for the triptans within the somatosensory thalamus. Both microiontophoretically applied and intravenous(More)
Most patients with primary headache syndromes who have frequent attacks of pain have tenderness in the sub-occipital region. Injection of the greater occipital nerve (GON) with local anesthetic and corticosteroids has been widely used in clinical practice for many years, yet there is no clear understanding of its mechanisms of action. Moreover, there is no(More)
OBJECTIVE To study the role of GABA receptors in thalamic relay neurons in the ventroposteromedial (VPM) nucleus of the rat activated by a trigeminovascular nociceptive stimulus in relationship to migraine, and the potential modulation of nociceptive transmission by GABA acting anti-convulsants. METHODS Trigeminovascular nociceptive afferents were(More)
1353-8020/$ – see front matter 2013 Elsevier Ltd. http://dx.doi.org/10.1016/j.parkreldis.2013.03.012 Fig. 1. Our patient with clear torticollis to the right. Idiopathic cervical dystonia (CD) is the most frequent form of focal dystonia and is characterized by sustained involuntary muscle contraction and/or twitching of cervical musculature resulting in the(More)
Clinical observations and genetic studies have suggested a role for high-threshold voltage-dependent calcium channels (VDCCs) in the pathogenesis of migraine. This study investigated the role of P/Q-, L- and N-type VDCCs in post-synaptic action potential generation in trigeminovascular nociceptive afferents in the trigeminocervical complex (TCC) of the cat(More)
Respiratory diseases of swine cause major economic losses. In many cases, respiratory disease losses are not recognized because death losses are low and reduced feed efficiencies are the primary effect. The major infectious organisms currently associated with swine pneumonias are Mycoplasma hyopneumoniae, Pasteurella multocida, Bordetella bronchiseptica,(More)