Kevin Sangster

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At present, the diagnosis of renal allograft rejection requires a renal biopsy. Clinical management of renal transplant patients would be improved by the development of non-invasive markers of rejection that can be measured frequently. This study sought to determine whether such candidate proteins can be detected in urine using mass spectrometry. Four(More)
BACKGROUND Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC). METHODS Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of > or =10 mg l(-1) or modified Glasgow prognostic score(More)
A total of 98 breast aspirates from patients with breast cancer have been fixed and stained for oestrogen receptors using the Abbott ERICA kit. In a preliminary series of 41 aspirates, cytochemical staining index (% cells staining x mean intensity) related to the receptor concentration determined biochemically on a subsequent biopsy with a correlation(More)
AMONG the properties of human breast carcinomata which have been correlated with the likelihood of response to endo-crine therapy are elastosis and high-affinity oestrogen binding activity. Tumours showing elastosis have been reported to have a better prognosis and to be more likely to respond to adrenal-ectomy than those without this feature (Shivas and(More)
The oestrogen receptor (ER) is considered to be an essential component of the mechanism of response of a breast tumour to endocrine therapy, but ER measurements have proved to have only modest predictive value. In the present study, we have examined ER status by both immunocytochemical assay (ER-ICA) on a fine needle aspirate and by radioligand-binding(More)
The presence or absence of an oestrogen receptor-related antigen in breast tumours has been examined histochemically using a monoclonal antibody ('Ds' - Coffer & King, 1981). In frozen sections, fixed either by the method of Tamura et al. (1980) or in methanol, staining was apparent in 14/24 (58%) and 22/26 (85%) of the breast cancers respectively. In(More)
This study attempted to reproduce an experiment which claimed that histochemical assessment of pentose-shunt activity of human breast tumors maintained in the presence and absence of hormones can provide a reliable index for response to endocrine therapy. 3 experimental techniques for frozen sectioning were tried: in Group 1 (CO2 quick-frozen) 6/14(More)
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