Kevin N Sheth

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Purification of serine racemase: biosynthesis of the neuromodulator D-serine.

Herman Wolosker, Kevin N Sheth, +4 authors Solomon H Snyder
Proceedings of the National Academy of Sciences…
1999

High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate receptors. In glial cultures of rat cerebral cortex, D-serine… (More)

Manifestations of the hyperadrenergic state after acute brain injury.

Holly E. Hinson, Kevin N Sheth
Current opinion in critical care
2012

PURPOSE OF REVIEW Hyperadrenergic activity leading to autonomic dysfunction after acute brain injury is an underrecognized, yet important source of complications following a variety of neurologic… (More)

Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

Kevin N Sheth, Jordan Jaskwhich Elm, +8 authors William Taylor Kimberly
The Lancet Neurology
2016

BACKGROUND Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether intravenous glyburide (RP-1127; glibenclamide) would… (More)

Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage

Minshu Li, Zhiguo Li, +5 authors F D Shi
Journal of cerebral blood flow and metabolism…
2017

Microglia are the first responders to intracerebral hemorrhage, but their precise role in intracerebral hemorrhage remains to be defined. Microglia are the only type of brain cells expressing the… (More)

Brief episodes of intracranial hypertension and cerebral hypoperfusion are associated with poor functional outcome after severe traumatic brain injury.

Deborah M. Stein, Peter Fu-Ming Hu, +5 authors Thomas M. Scalea
The Journal of trauma
2011

BACKGROUND Management strategies after severe traumatic brain injury (TBI) target prevention and treatment of intracranial hypertension (ICH) and cerebral hypoperfusion (CH). We have previously… (More)

Glyburide is associated with attenuated vasogenic edema in stroke patients.

William Taylor Kimberly, Thomas W. K. Battey, +7 authors Kevin N Sheth
Neurocritical care
2014

BACKGROUND Brain edema is a serious complication of ischemic stroke that can lead to secondary neurological deterioration and death. Glyburide is reported to prevent brain swelling in preclinical… (More)

Traditional systolic blood pressure targets underestimate hypotension-induced secondary brain injury.

Megan L. Brenner, Deborah M. Stein, Peter Fu-Ming Hu, Bizhan Aarabi, Kevin N Sheth, Thomas M. Scalea
The journal of trauma and acute care surgery
2012

BACKGROUND Vital signs, particularly blood pressure, are often manipulated to maximize perfusion and optimize recovery from severe traumatic brain injury (sTBI). We investigated the utility of… (More)

Higher volume endovascular stroke centers have faster times to treatment, higher reperfusion rates and higher rates of good clinical outcomes.

Rishi K. Gupta, Anat Horev, +17 authors R G Nogueira
Journal of neurointerventional surgery
2013

BACKGROUND AND PURPOSE Technological advances have helped to improve the efficiency of treating patients with large vessel occlusion in acute ischemic stroke. Unfortunately, the sequence of events… (More)

Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema

Sebastian Urday, William Taylor Kimberly, +5 authors Kevin N Sheth
Nature Reviews Neurology
2015

Perihaematomal oedema (PHO) is an important pathophysiological marker of secondary injury in intracerebral haemorrhage (ICH). In this Review, we describe a novel method to conceptualize PHO formation… (More)

Managing malignant cerebral infarction.

J. Marc Simard, Juan Sahuquillo, Kevin N Sheth, Kristopher Thomas Kahle, Brian Patrick Walcott
Current treatment options in neurology
2011

OPINION STATEMENT Managing patients with malignant cerebral infarction remains one of the foremost challenges in medicine. These patients are at high risk for progressive neurologic deterioration and… (More)

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