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PURPOSE Andrographolide is a diterpenoid lactone isolated from Andrographis paniculata (King of Bitters), an herbal medicine used in Asia. It has been reported to have anti-inflammatory, antihypertensive, antiviral, and immune-stimulant properties. Furthermore, it has been shown to inhibit cancer cell proliferation and induce apoptosis in leukemia and solid(More)
Arsenic trioxide (ATO) is an effective therapeutic agent for acute promyelocytic leukaemia (APL) (Evens et al, 2004). In APL, ATO induces differentiation at low concentrations, while inducing apoptosis at higher concentrations (Miller et al, 2002). In addition, ATO-induced apoptosis in APL is mediated through the mitochondrial apoptotic pathway, resulting(More)
BACKGROUND Lesbian, gay, bisexual, and transgender (LGBT) populations have smoking rates twice that of their heterosexual counterparts. To design effective outreach, prevention, and treatments for these individuals, a comprehensive understanding of associated factors is needed. OBJECTIVE To increase understanding of how social integration and(More)
Congenital and acquired diseases of the heart, such as heart valve degradation, great artery dysfunction, and coronary artery blockage are the leading causes of morbidity and mortality in the United States and developed countries today. A large fraction of the total costs that the nation spends on health care can be attributed to tissue loss or organ(More)
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