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Component-based software structuring principles are now commonplace at the application level; but componentization is far less established when it comes to building low-level systems software. Although there have been pioneering efforts in applying componentization to systems-building, these efforts have tended to target specific application domains (e.g.,(More)
A new class of data storage systems, called NoSQL (Not Only SQL), have emerged to complement traditional database systems, with rejection of general ACID transactions as one common feature. Different platforms, and indeed different primitives within one NoSQL platform, can offer various consistency properties, from Eventual Consistency to single-entity(More)
Current techniques in biological resurfacing of cartilage defects require an open arthrotomy or arthroscopy and involve the direct transplantation of isolated cells and/or scaffolds or whole tissue grafts with chondrogenic potential onto the cartilage defect. Our study investigates the possibility of direct intra-articular injection of mesenchymal stem(More)
Cloud computing allows dynamic resource scaling for enterprise online transaction systems, one of the key characteristics that differentiates the cloud from the traditional computing paradigm. However, initializing a new virtual instance in a cloud is not instantaneous; cloud hosting platforms introduce several minutes delay in the hardware resource(More)
OBJECTIVE To develop a novel prenatal assay based on selective analysis of cell-free DNA in maternal blood for evaluation of fetal Trisomy 21 (T21) and Trisomy 18 (T18). METHODS Two hundred ninety-eight pregnancies, including 39 T21 and seven T18 confirmed fetal aneuploidies, were analyzed using a novel, highly multiplexed assay, termed digital analysis(More)
For ontologies represented as Description Logic Tboxes, op-timised DL reasoners are able to detect logical errors, but there is comparatively limited support for resolving such problems. One possible remedy is to weaken the available information to the extent that the errors disappear, but to limit the weakening process as much as possible. The most obvious(More)
PURPOSE To analyze the results of the use of intra-articular cultured autologous bone marrow-derived mesenchymal stem cell (MSC) injections in conjunction with microfracture and medial opening-wedge high tibial osteotomy (HTO). METHODS Fifty-six knees in 56 patients with unicompartmental osteoarthritic knees and genu varum were randomly allocated to the(More)
We prospectively compared the clinical outcomes and patient satisfaction rates of aseptic (n=30) versus septic revision TKA (n=15) at a mean follow-up of 40 months. We hypothesized that the clinical results of septic revision TKA would be inferior to aseptic revision TKA. The indication for revision in aseptic group was stiffness in 11 patients, aseptic(More)
The synovial joint arises from an initial condensation of cells that subsequently develops into distinct skeletal structures, separated by the joint. Bone morphogenetic proteins (BMPs) and growth and differentiation factors (GDFs) have a fundamental role during skeletogenesis, including joint formation. Development of the joint appears to be dependent on(More)