Kevin L. Gordish

  • Citations Per Year
Learn More
Resveratrol is suggested to have beneficial cardiovascular and renoprotective effects. Resveratrol increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) synthesis. We hypothesized resveratrol acts as an acute renal vasodilator, mediated through increased NO production and scavenging of reactive oxygen species (ROS). In(More)
Parathyroid hormone-related protein (PTHrP) increases renin release from isolated perfused kidneys and may act as an autacoid regulator of renin secretion, but its effects on renin in vivo are unknown. In vivo, PTHrP causes hypercalcemia and anorexia, which may affect renin. We hypothesized that chronically elevated PTHrP would increase plasma renin(More)
Resveratrol is reported to exert cardio-renal protective effects in animal models of pathology, yet the mechanisms underlying these effects are poorly understood. Previously, we reported an i.v. bolus of resveratrol induces renal vasodilation by increasing nitric oxide bioavailability and inhibiting reactive oxygen species. Thus, we hypothesized a sustained(More)
Previously, we reported that 20% fructose diet causes salt-sensitive hypertension. In this study, we hypothesized that a high salt diet supplemented with 20% fructose (in drinking water) stimulates salt-sensitive hypertension by increasing salt retention through decreasing renal nitric oxide. Rats in metabolic cages consumed normal rat chow for 5 days(More)
Resveratrol is reported to reduce blood pressure in animal models of hypertension, but the mechanisms are unknown. We have shown that resveratrol infusion increases sodium excretion. We hypothesized that chronic ingestion of resveratrol would reduce angiotensin II (Ang II)-induced increases in blood pressure by decreasing oxidative stress and by also(More)
Atchison DK, Westrick E, Szandzik DL, Gordish KL, Beierwaltes WH. Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake. Am J Physiol Endocrinol Metab 303: E457–E463, 2012. First published May 29, 2012; doi:10.1152/ajpendo.00020.2012.—Parathyroid hormone-related protein (PTHrP) increases(More)
21 22 Corresponding author: 23 Prof. William H. Beierwaltes, Ph.D. 24 Senior Research Scientist, 25 Dept. Internal Medicine, 26 Hypertension and Vascular Research Div., 27 Henry Ford Hospital 28 7121 E&R Bldg., 2799 W. Grand Blvd., Detroit, MI 48202 29 313-916-7494, FAX 313-916-5284, 30 31 32 33 34 35 Articles in PresS. Am J Physiol(More)
<lb>THE ACUTE AND CHRONIC EFFECTS OF RESVERATROL ON RENAL FUNCTION<lb>AND BLOOD PRESSURE<lb>by<lb>KEVIN L. GORDISH<lb>August 2015<lb>Advisor: Dr. William Beierwaltes<lb>Major: Physiology<lb>Degree: Doctor of Philosophy<lb>We investigated the acute and chronic effects of resveratrol on renal function and<lb>blood pressure. We hypothesized that resveratrol(More)
  • 1