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A review of previous experiments on the pitch of vibrato tones and the reasons why a new measurement was needed are given. A method of adjustment was used to find the pitch for tones with center frequencies of 220, 440, 880, and 1500 Hz, with total nominal vibrato widths of 50, 100, and 200 cents, and vibrato rates of 4, 6, and 8 Hz. In one case a complex(More)
BACKGROUND Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is the difficulty to pinpoint their much shorter functional sub-features, such as catalytically relevant sequence motifs in enzymes or ligand binding signatures of receptor proteins. (More)
MOTIVATION The ability to accurately measure structural similarities among small molecules is important for many analysis routines in drug discovery and chemical genomics. Algorithms used for this purpose include fragment-based fingerprint and graph-based maximum common substructure (MCS) methods. MCS approaches provide one of the most accurate similarity(More)
Acknowledgments I am deeply grateful to my adviser, Dr. Christian R. Shelton, for his invaluable mentoring. Without his help I would not have been able to complete this dissertation. I thank my committee members: Dr. Lonardi for his technical advise, Dr. Hanne-man for his time and advice with social network analysis, and Dr. Keogh for his generous support(More)
Acknowledgments I would like to begin by thanking my advisor, Dr. Christian R. Shelton, for his mentoring, support, and extreme patience over the years. It was a privilege to be a part of his research group. His dedication to research and teaching, his knowledge, his brilliant mind and character will always be an inspiration. for the chance to work on a(More)
Acknowledgments There are many people to whom I owe many thanks for helping me going through this long process of completing a Ph.D. First and foremost, I would like to express my gratitude to my advisor, Dr. Christian R. Shelton, for his unending support, extremely constructive feedback, excellent supervision, and all the encouragement over the last five(More)
Acknowledgements The journey of writing a PhD dissertation can be discouraging and lonely. I could not have achieved these results without all the kind help from numerous people around me. I could not have started my PhD career and hence written the thesis without the guidance September 2004 as a PhD student. Since then he gave me careful guidance for my(More)
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