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Today's top high performance computing systems run applications with hundreds of thousands of processes, contain hundreds of storage nodes, and must meet massive I/O requirements for capacity and performance. These leadership-class systems face daunting challenges to deploying scalable I/O systems. In this paper we present a case study of the I/O challenges(More)
Computational science applications are driving a demand for increasingly powerful storage systems. While many techniques are available for capturing the I/O behavior of individual application trial runs and specific components of the storage system, continuous characterization of a production system remains a daunting challenge for systems with hundreds of(More)
—High-performance computing (HPC) and distributed systems rely on a diverse collection of system software to provide application services, including file systems, schedulers, and web services. Such system software services must manage highly concurrent requests, interact with a wide range of resources, and scale well in order to be successful.(More)
AIMS To compare treatment regimens of two widely used natural surfactant preparations Curosurf and Survanta in respiratory distress syndrome (RDS). METHODS The effects of the two treatment regimens on gas exchange, ventilatory requirements, and 28 day outcome in infants with RDS were compared. Seventy five preterm infants (birth weight 700-1500 g) with(More)
SUMMARY. Continuous therapy with antistaphylococcal antibiotics is advocated by some cystic fibrosis (CF) centers, but it is unclear whether this strategy favors early colonization with P. aeruginosa. We used the data base for the German Centers of the European Registry for Cystic Fibrosis (ERCF) to assess the effect of continuous antistaphyloccocal therapy(More)
OBJECTIVE Connatal pneumonia caused by group B streptococcal (GBS) infection may be associated with surfactant dysfunction. We investigated the effects of surfactant treatment in term and preterm neonates with GBS infection and respiratory failure, in comparison with corresponding data from a control population of noninfected infants treated with surfactant(More)
There is now convincing evidence that the severity of neonatal respiratory distress syndrome can be reduced by surfactant replacement therapy; however, the optimal therapeutic regimen has not been defined. This randomized European multicenter trial was designed to determine whether the beneficial effects of a single large dose of Curosurf (200 mg/kg) in(More)
Data from 4081 vaginal deliveries (no caesarean sections) were analyzed retrospectively (IBM 730/158) with regard to duration of second and "final stage" of labour and fetal outcome (acid-base balance and apgar scores). The average duration of the two periods amounted to 22.8+/-29.6 and 9.9+/-7.8 min. Mean pH (UA) was 7.268+/-0.084 and the acidotic risk (pH(More)
OBJECTIVE To clarify the effectiveness of amoxicillin prophylaxis in the prevention of catheter-related infections. METHOD We performed a randomized, controlled, sequential, prospective trial in newborn infants undergoing percutaneous central venous catheterization. RESULTS Seventy-five infants (median birth weight, 1240 gm; median age at catheter(More)
OBJECTIVE To study the efficiency of a heated humidifier and a heat and moisture exchanger in mechanically ventilated neonates and infants. DESIGN Prospective, controlled, clinical study. SETTING University pediatric intensive care unit. PATIENTS Forty neonates and infants who needed mechanical ventilation were enrolled in the study. INTERVENTIONS(More)