Kevin Gaffney

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The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this "miracle herb" in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (BZM) is a proteasome inhibitor in clinical use for multiple myeloma. Here, we investigated whether the(More)
BACKGROUND An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex) is mediated primarily via the inhibition of COX-2. We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog,(More)
Epoxy molding compounds have been developed which can simultaneously underfill and overmold the Flip Chip die in a single transfer molding process. Transfer molding is a well-defined industry process; with suitable mold design, these materials can utilize the currently installed capital base. The ability to apply pressure during the molding process can(More)
Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, which complicates mechanistic studies and drug development.(More)
Title Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors Abstract The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this 'miracle herb' in hopes of augmenting the anticancer outcome of their(More)
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