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In five patients with mesial temporal sclerosis, the authors verified the precision and reproducibility of hippocampal segmentations with deformation-based magnetic resonance (MR) imaging. The overall percentage overlap between automated segmentations was 92.8% (SD, 3.5%), between manual segmentations was 73.1% (SD, 9.5%), and between automated and manual(More)
PURPOSE To determine whether automatic and manual measurements of hippocampal volume differences on MRI between normal aging, cognitive impairment (CI), and Alzheimer's disease (AD) yield similar results. MATERIALS AND METHODS Reliability was determined for an automatic and a manual method on nine volunteers (22-83 years old) who underwent MRI twice in 1(More)
Cochlear nerve discharge patterns in response to the synthesized consonant-vowel stimulus /da/ were collected from a population of 223 auditory-nerve fibers from a single cat. For each nerve fiber, discharges were measured from multiple, independent stimulus presentations, with the means and variances of the post-stimulus time histograms and Fourier(More)
A new language model incorporating both N-gram and context-free ideas is proposed. This constrained context-free model is speciied by a stochastic context-free prior distribution with N-gram frequency constraints. The resulting distribution is a Markov random eld. Algorithms for sampling from this distribution and estimating the parameters of the model are(More)
Auditory-nerve fiber discharges are modeled as self-exciting point processes with intensity given by the product of a stimulus-related function and a refractory-related function. Previous methods of estimating these two functions, based on the maximum-likelihood principle, have the problem of estimating more parameters than the data can support. A new(More)
We determined that signal transducer and activator of transcription 3 (Stat3) is tyrosine phosphorylated in 37% of primary breast tumors and 63% of paired metastatic axillary lymph nodes. Examination of the distribution of tyrosine phosphorylated (pStat3) in primary tumors revealed heterogenous expression within the tumor with the highest levels found in(More)
Structural hippocampal magnetic resonance (MR) imaging-based analysis is helpful in the diagnosis and treatment of mesial temporal epileptic seizures. Computational anatomic techniques provide a framework for objective assessment of three-dimensional hippocampal structure. We applied a previously validated technique of deformation-based hippocampal(More)