Kevin E. Finucane

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To refine the functional guidelines for operability for lung resection, we prospectively studied 55 consecutive patients with suspected lung malignancy thought to be surgically resectable. Lung function and exercise capacity were measured preoperatively and at 3 and 12 months postoperatively. Preoperative pulmonary scintigraphy was used to calculate the(More)
To examine respiratory muscle recruitment pattern during inspiratory loading and role of fatigue in limiting endurance, we studied seven normal subjects on 17 +/- 6 days during breathing against progressive inspiratory threshold load. Threshold pressure (Pth) was progressively increased 14 +/- 5 cmH2O every 2 min until voluntary cessation (task failure).(More)
Snoring and obstructive sleep apnea (OSA) are related to narrowing of the upper airway. A mandibular advancement splint (MAS) could improve both conditions by increasing oropharyngeal and hypopharyngeal dimensions. The effects of a MAS on snoring and OSA was evaluated 3.5 +/- 2.1 (mean +/- SD) mo after issue in 57 subjects with habitual loud snoring, 39 of(More)
Muscle efficiency increases with fiber length and decreases with load. Diaphragm efficiency (Eff(di)) in healthy humans, measured as power output (Wdi) relative to the root mean square of diaphragm electromyogram (RMS(di)), increases with hyperpnea due to phasic activity of abdominal muscles acting to increase diaphragm length at end expiration (L(di ee))(More)
Hyperpnea with exercise or hypercapnia causes phasic contraction of abdominal muscles, potentially lengthening the diaphragm at end expiration and unloading it during inspiration. Muscle efficiency in vitro varies with load, fiber length, and precontraction stretch. To examine whether these properties of muscle contractility determine diaphragm efficiency(More)
The pattern of breathing was studied in 8 patients with acute severe asthma on admission to hospital and during recovery to determine how chest wall motion varied with the degree of air-flow obstruction (AO), the relationship between degree of AO and respiratory timing and ventilation, and whether the pattern suggested respiratory muscle fatigue when asthma(More)
To compensate for diaphragmatic weakness, intercostal/accessory muscles may be recruited in inspiration and/or abdominal muscles in expiration with relaxation during subsequent inspiration. As a consequence, for a given decrease in pleural pressure (Ppl) during quiet inspiration (qi), abdominal pressure (Pab) should either undergo a smaller increase than(More)