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Steganography is the science that involves communicating secret data in an appropriate multimedia carrier, e.g., image, audio, and video files. It comes under the assumption that if the feature is visible, the point of attack is evident, thus the goal here is always to conceal the very existence of the embedded data. Steganography has various useful(More)
We report on 16 patients with relapsed or refractory B cell acute lymphoblastic leukemia (B-ALL) that we treated with autologous T cells expressing the 19-28z chimeric antigen receptor (CAR) specific to the CD19 antigen. The overall complete response rate was 88%, which allowed us to transition most of these patients to a standard-of-care allogeneic(More)
Adults with relapsed B cell acute lymphoblastic leukemia (B-ALL) have a dismal prognosis. Only those patients able to achieve a second remission with no minimal residual disease (MRD) have a hope for long-term survival in the context of a subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We have treated five relapsed B-ALL subjects(More)
Challenges face biometrics researchers and particularly those who are dealing with skin tone detection include choosing a colour space, generating the skin model and processing the obtained regions to fit applications. The majority of existing methods have in common the de-correlation of luminance from the considered colour channels. Luminance is(More)
Steganography is defined as the science of hiding or embedding ";data"; in a transmission medium. Its ultimate objectives, which are undetectability, robustness (i.e., against image processing and other attacks) and capacity of the hidden data (i.e., how much data we can hide in the carrier file), are the main factors that distinguish it from other ";(More)
The mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. While showing clinical efficacy in a subset of tumors, rapamycin and rapalogs are specific and allosteric inhibitors of mTOR complex 1 (mTORC1), but they do not directly inhibit mTOR complex 2 (mTORC2), an emerging player in cancer. Here, we report(More)
This paper presents a novel dynamic threshold approach to discriminate skin pixels and non-skin pixels in color images. Fixed decision boundaries (or fixed threshold) classification approaches are successfully applied to segment human skin. These fixed thresholds mostly failed in two situations as they only search for a certain skin color range: 1) any(More)
The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway that is dysregulated in 50% of all human malignancies. Rapamycin and its analogues (rapalogs) partially inhibit mTOR through allosteric binding to mTOR complex 1 (mTORC1) but not mTOR complex 2 (mTORC2), an emerging player in cancer.(More)
Pigment cells of the zebrafish, Danio rerio, offer an exceptionally tractable system for studying the genetic and cellular bases of cell fate decisions. In the zebrafish, neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores, iridescent iridophores and black melanophores. In this study, we present evidence for a(More)
The recent digital revolution has facilitated communication, data portability and on-thefly manipulation. Unfortunately, this has brought along some critical security vulnerabilities that put digital documents at risk. The problem is in the security mechanism adopted to secure these documents by means of encrypted passwords; however, this security shield(More)