Kevin C. Osterhoudt

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The mechanism of cellular uptake of cadmium, a highly toxic metal ion, is not known. We have studied cadmium uptake and toxicity in an established secretory cell line, GH4C1, which has well characterized calcium channels. Nimodipine, an antagonist of voltage-sensitive calcium channels, protected cells against cadmium toxicity by increasing the LD50 for(More)
OBJECTIVES The 23-hour observation units (OUs) may be used to avoid unnecessary hospital admissions. However, unexpected hospitalizations from the 23-hour OUs involve transfer of care and may decrease the efficiency and safety of care of the patient and the unit itself. The primary objective of this study was to determine the predictors of unexpected(More)
OBJECTIVE To initiate investigation into the medication errors that occur in a pediatric emergency department. These errors have the potential for significant morbidity and mortality, as well as costly litigation. METHODS We conducted a retrospective chart review of all medication and intravenous fluid errors identified in a pediatric emergency department(More)
To the Editor: Reports to U.S. poison control centers of possible nicotine toxicity tripled from 2012 to 2013.1,2 Although nicotine toxicity is not a new phenomenon, the emergence of electronic cigarettes (“e-cigarettes”) has spawned a market for highly concentrated liquid nicotine. This phenomenon has resulted in unprecedented access to potentially toxic(More)
Short-Stay Emergency Department Observation Units (OU) are an alternative to hospitalization, but data on OU care of pediatric poisoning exposures is limited. We report the experience of a pediatric OU with this population. We retrospectively reviewed the charts of children with poison exposure admitted to a pediatric OU during a 30-month period. Data was(More)
OBJECTIVES Vomiting frequently complicates the administration of activated charcoal. The incidence of such vomiting is not defined precisely in the pediatric population. Little is known about the patient-, poison-, or procedure-specific factors that contribute to emesis of charcoal. This study aimed to estimate the incidence of vomiting subsequent to(More)
Idiopathic ketotic hypoglycemia (IKH) is an important cause of emergent hypoglycemia among children. We present a case series of 24 patients with IKH in an effort to provide a current clinical description of this disorder. Secondly, we provide a crude lower-bound estimate of the incidence of IKH in an Emergency Department (ED) setting. The charts of 94(More)
A 26-month-old boy was taken to the Emergency Department (ED) with the concern that he had ingested his mother’s oral hypoglycemic medication. He and his 4-year-old sister had been caught playing with their mother’s pill bottles, and the girl admitted to giving him one pill to eat. Although the implicated pills could be positively identified as(More)
BACKGROUND Extracorporeal membrane oxygenation (ECMO) may serve as a bridge to regain cardiac function in refractory resuscitation. However, its use has so far been limited owing to low availability, especially in emergency departments. OBJECTIVES To describe two children with acute myocarditis successfully treated with ECMO in the emergency department of(More)