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OBJECTIVE To investigate associations between physical activity at age 12 and subsequent adiposity at age 14. DESIGN Prospective birth cohort study with data collected between 2003 and 2007. SETTING Original recruitment in 1991-2 of 14,541 pregnant women living in the former County of Avon (United Kingdom). PARTICIPANTS At age 12, 11,952 children were(More)
OBJECTIVE Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA is increased in individuals with high bone mass (HBM), in whom BMD is assumed to be elevated due to a primary genetic cause. METHODS A total of 335,115 DXA scans were screened to identify(More)
CONTEXT The factors that govern skeletal responses to physical activity remain poorly understood. OBJECTIVE The aim of this study was to investigate whether gender or fat mass influences relationships between cortical bone and physical activity, after partitioning accelerometer outputs into low (0.5-2.1 g), medium (2.1-4.2 g), or high (>4.2 g) impacts,(More)
PURPOSE Time spent in "sports/outdoor activity" has shown a negative association with incident myopia during childhood. We investigated the association of incident myopia with time spent outdoors and physical activity separately. METHODS Participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) were assessed by noncycloplegic(More)
Obesity is a risk factor for fibromyalgia in adults, but whether a similar relationship exists in children is uncertain. This study examined whether obesity is associated with reporting of musculoskeletal pain, including chronic regional pain (CRP) and chronic widespread pain (CWP), in adolescents, in a population-based setting. A pain questionnaire was(More)
Whether a certain level of impact needs to be exceeded for physical activity (PA) to benefit bone accrual is currently unclear. To examine this question, we performed a cross-sectional analysis between PA and hip BMD in 724 adolescents (292 boys, mean 17.7 years) from the Avon Longitudinal Study of Parents and Children (ALSPAC), partitioning outputs from a(More)
CONTEXT The intensity of habitual physical activity (PA) needed to affect skeletal development in childhood is currently unclear. OBJECTIVE To examine associations between light PA, moderate PA, and vigorous PA (as assessed by accelerometry), and tibial cortical bone mass (BMC(C)) as measured by peripheral quantitative computed tomography. (More)
OBJECTIVE Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14-year-old children from a(More)
We hypothesized that bone resorption acts to increase bone strength through stimulation of periosteal expansion. Hence, we examined whether bone resorption, as reflected by serum β-C-telopeptides of type I collagen (CTX), is positively associated with periosteal circumference (PC), in contrast to inverse associations with parameters related to bone(More)
CONTEXT Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development. OBJECTIVE The aim of the study was to evaluate associations between im fat, as reflected by muscle density as measured by peripheral quantitative computed tomography, and cortical bone parameters in young adults. (More)