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Objectives: Ceftaroline + avibactam (NXL104) is a novel inhibitor combination active against Enterobacteria-ceae with class A and C b-lactamases. We investigated its risk of mutational resistance. Methods: Single-and multi-step mutants were sought and characterized from Enterobacteriaceae with extended-spectrum b-lactamases (ESBLs), AmpC b-lactamases and(More)
Background.  Acute kidney injury (AKI) is a well recognized complication of severe malaria in adults, but the incidence and clinical importance of AKI in pediatric severe malaria (SM) is not well documented. Methods.  One hundred eighty children aged 1 to 10 years with SM were enrolled between 2011 and 2013 in Uganda. Kidney function was monitored daily for(More)
Acknowledgements The authors want to shine a bright light on the tireless and unflaggingly creative members of the Governor's team that brought 270 people together in Los Angeles so seamlessly: assistance, and Alison Koppe and Meredith Pressfield for their substantive research and contributions to this report. They are grateful to Claire Van Camp for her(More)
Malaria is a major cause of morbidity and mortality in sub-Saharan Africa, and poor outcomes have been associated with endothelial activation. In this study, biomarkers of endothelial activation, haemostasis, and thrombosis were measured in Ugandan children with severe malaria who participated in a clinical trial, in order to investigate associations(More)
Monkeys are a valuable model for investigating the structure and function of the brain. To attain the requisite resolution to resolve fine anatomical detail and map localized brain activation requires radiofrequency (RF) coils that produce high signal-to-noise ratios (SNRs) both spatially (image SNR) and temporally. Increasing the strength of the static(More)
Background.  Host responses to infection are critical determinants of disease severity and clinical outcome. The development of tools to risk stratify children with malaria is needed to identify children most likely to benefit from targeted interventions. Methods.  This study investigated the kinetics of candidate biomarkers of mortality associated with(More)
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