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OBJECTIVES Ceftaroline + avibactam (NXL104) is a novel inhibitor combination active against Enterobacteriaceae with class A and C β-lactamases. We investigated its risk of mutational resistance. METHODS Single- and multi-step mutants were sought and characterized from Enterobacteriaceae with extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases and(More)
PURPOSE Two-dimensional ultrasound (2D US) imaging is commonly used for diagnostic and intraoperative guidance of interventional liver procedures; however, 2D US lacks volumetric information that may benefit interventional procedures. Over the past decade, three-dimensional ultrasound (3D US) has been developed to provide the missing spatial information. 3D(More)
Objectives: Ceftaroline + avibactam (NXL104) is a novel inhibitor combination active against Enterobacteria-ceae with class A and C b-lactamases. We investigated its risk of mutational resistance. Methods: Single-and multi-step mutants were sought and characterized from Enterobacteriaceae with extended-spectrum b-lactamases (ESBLs), AmpC b-lactamases and(More)
Acknowledgements The authors want to shine a bright light on the tireless and unflaggingly creative members of the Governor's team that brought 270 people together in Los Angeles so seamlessly: assistance, and Alison Koppe and Meredith Pressfield for their substantive research and contributions to this report. They are grateful to Claire Van Camp for her(More)
Monkeys are a valuable model for investigating the structure and function of the brain. To attain the requisite resolution to resolve fine anatomical detail and map localized brain activation requires radiofrequency (RF) coils that produce high signal-to-noise ratios (SNRs) both spatially (image SNR) and temporally. Increasing the strength of the static(More)
PURPOSE In current clinical practice, there is no integrated 3D ultrasound (3DUS) guidance system clinically available for breast brachytherapy. In this study, the authors present a novel robot-assisted 3DUS system for real-time planning and guidance of breast interstitial high dose rate (HDR) brachytherapy treatment. METHODS For this work, a new computer(More)
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