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The aromatic fatty acid phenylbutyrate (PB) induces cytostasis, differentiation, and apoptosis in primary myeloid leukemic cells at clinically achievable concentrations. In the present study, we have investigated the structural and cellular basis for PB-induced cytostasis, using the ML-1 human myeloid leukemia cell line as a model system. PB induced a(More)
Despite preliminary evidence of clinical activity of the putative differentiating agent sodium phenylbutyrate (PB) in the treatment of myeloid neoplasms, it has proven difficult to maintain therapeutic levels of PB above 0.5 mM, well below the ED50 of 1-2 mM. We have studied the impact of combining PB with all-trans retinoic acid (ATRA) on the ML-1 myeloid(More)
Calculation of the radiation dose at the cellular level is given for several radionuclides that appear promising for radioimmunotherapy using the radiation dose distribution from a point source. The radionuclides have half-lives in the 1-3 day range and have electron ranges up to several hundred micrometers. The investigation emphasizes the physical(More)
Two-dimensional arborols are bolaform amphiphiles in which a central, hydrophobic spacer separates twin hydrophilic ends. Under appropriate conditions, these relatively small molecules assemble into very long fibers; subsequently, the system gels if the arborol concentration is sufficiently high. The diffusion of linear or slightly branched dextran probes(More)
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