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Nervous system development takes place after positional information has been established along the dorsal-ventral (D/V) axis. The initial subdivision provided by a gradient of nuclear dorsal protein is maintained by the zygotic genes expressed along the D/V axis. In this study, an investigation was conducted to determine the range of Dpp function in(More)
Polycomb group (PcG) proteins are negative regulators that maintain the expression of homeotic genes and affect cell proliferation. Pleiohomeotic (Pho) is a unique PcG member with a DNA-binding zinc finger motif and was proposed to recruit other PcG proteins to form a complex. The pho null mutants exhibited several mutant phenotypes such as the(More)
Neurogenesis in Drosophila melanogaster is initiated by an ordered appearance of neuroblasts arranged in three columns (medial, intermediate, and lateral) in the neuroectoderm. In each column, specific homeodomain-containing genes are expressed. The ventral nervous system defective (vnd) regulates the fate of the cells in the medial domain of the(More)
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