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Clinical trials rarely, if ever, occur in a vacuum. Generally, large amounts of clinical data are available prior to the start of a study, particularly on the current study's control arm. There is obvious appeal in using (i.e., 'borrowing') this information. With historical data providing information on the control arm, more trial resources can be devoted(More)
SUMMARY Accurate determination of extracted ion chromatographic peak areas in isotope-labeled quantitative proteomics is difficult to automate. Manual validation of identified peaks is typically required. We have integrated a peak confidence scoring algorithm into existing tools which are compatible with analysis pipelines based on the standards from the(More)
Studies investigating the relationship between the use of inflectional morphology and speech-perception abilities in children with SLI traditionally have employed synthetic speech stimuli. The purpose of this study was to replicate the findings reported in Leonard, McGregor, and Allen (1992) with an older group of children with SLI and to determine if the(More)
Many standard methods for modeling interaction in two way ANOVA require mn interaction parameters, where m and n are the number of rows and columns in the table. By viewing the interaction parameters as a matrix and performing a singular value decomposition, one arrives at the Additive Main EEects and Multiplicative Interaction (AMMI) model which is(More)
OBJECTIVES Sepsis is the tenth leading cause of death in the United States. Despite extensive research, mortality rates for sepsis have not substantially improved in the last several decades. We describe an innovative phase II clinical trial design for evaluating the addition of L-carnitine to the treatment of vasopressor-dependent septic shock. DESIGN(More)
Within-subject statistical modeling techniques were employed to investigate individual differences in the extent to which two possible indicators of processing time predicted changes in utterance complexity during spontaneous discourse for 10 children ages 7;1 to 10;1 with specific language impairments (SLI) who differed in receptive language abilities. The(More)
This paper presents an overview of Bayesian and frequentist issues that arise in multivariate statistical modeling involving data mining. We discuss data cubes, structured query language computer commands, and the acquisition of data that violate the usual i.i.d. modeling assumptions. We address problems of multivariate exploratory data analysis, the(More)