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Expression of ABC-transport proteins in canine mammary cancer: consequences for chemotherapy.
Intrinsic or acquired drug resistance is a major barrier for chemotherapy of cancer. Importantly, the presence of ATP-binding cassette, ABC-transport proteins in tumour cells circumvents anExpand
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Determination of functional ABCG2 activity and assessment of drug-ABCG2 interactions in dairy animals using a novel MDCKII in vitro model.
The ATP-binding cassette subfamily G member 2 (ABCG2) transporter is a member of the ATP-binding cassette (ABC) family of efflux carriers that mediates cellular extrusion of various drugs and toxins.Expand
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Rat reduced-folate carrier-1 is localized basolaterally in MDCK kidney epithelial cells and contributes to the secretory transport of methotrexate and fluoresceinated methotrexate
The reduced-folate carrier (Rfc-1), previously also called methotrexate carrier-1 (MTX-1), was recently identified as accounting for approximately 30% of the methotrexate (Mtx) uptake into rat kidneyExpand
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The metastatic potential of canine mammary tumours can be assessed by mRNA expression analysis of connective tissue modulators.
Metastases are the crucial factor for the prognosis of canine mammary tumours (CMTs). In women, the peptide hormone relaxin is linked with metastatic breast cancer. Therefore, the impact of relaxinExpand
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Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization.
Previous Northern blot studies suggested strong expression of a homolog to the sodium-dependent hepatocellular methotrexate transporter in the kidneys. Here, we report on the cloning of the cDNA forExpand
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Molecular and functional evidence for a Na+–HCO3−-cotransporter in sheep ruminal epithelium
The present study aimed to identify the HCO3−-dependent mechanisms contributing to the homeostasis of the intracellular pH (pHi) in ruminal epithelial cells of sheep. Therefore, pHi was measuredExpand
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Bioelimination of histamine in epithelia of the porcine proximal colon of pigs
Abstract.Objective:The study aimed to gain insight into how intestinal histamine N-methyltransferase (HMT) and diamine oxidase (DAO) could contribute to bioelimination of histamine.Material andExpand
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Investigation of the local expression of the relaxin system in canine mammary tumours.
While mammary tumours are the main reasons of death in bitches, early detection of tumours and metastases is crucial for survival of affected dogs. Invasiveness and angiogenesis, which are importantExpand
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