Kerstin Lenk

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The idea that astrocytes may be active partners in synaptic information processing has recently emerged from abundant experimental reports. Because of their spatial proximity to neurons and their bidirectional communication with them, astrocytes are now considered as an important third element of the synapse. Astrocytes integrate and process synaptic(More)
Background: Measures of spike train synchrony are widely used in both experimental and computational neuroscience. Timescale independent and parameter-free measures, such as the ISI-distance, the SPIKE-distance and SPIKE-synchronization, are preferable to timescale parametric measures, since by adapting to the local firing rate they take into account all(More)
BACKGROUND Microelectrode array (MEA) is a widely used technique to study for example the functional properties of neuronal networks derived from human embryonic stem cells (hESC-NN). With hESC-NN, we can investigate the earliest developmental stages of neuronal network formation in the human brain. METHODS In this paper, we propose an in silico model of(More)
Astrocytes actively influence the behavior of the surrounding neuronal network including changes of the synaptic plasticity and neuronal excitability. These dynamics are altered in diseases like Alzheimer's, where the release of the gliotransmitter GABA is increased by affected, so called reactive astrocytes. In this paper, we aim to simulate a neural(More)
Synchrony and asynchrony are essential aspects of the functioning of interconnected neuronal cells and networks. New information on neuronal synchronization can be expected to aid in understanding these systems. Synchronization provides insight in the functional connectivity and the spatial distribution of the information processing in the networks.(More)
Neuronal networks are often studied in vitro using micro-electrode arrays (MEAs), where neurons are cultured on top of an electrode grid, and the action potentials can be recorded. This way the electrical activity of the network can be inspected at multiple locations simultaneously, which enables the studying of network behavior. A typical MEA has 60 of(More)
Our aim is to develop a simple model which is suitable to simulate concentration-response curves as observed in in-vitro experiments with multielectrode array (MEA) neurochips. In an in-vitro experiment approximately 10.000 neurons of the frontal cortex of embryonic mice [1] are cultivated on a MEA neurochip [2]. Neuro-active substances like bicuculline are(More)
Our aim is to design a model which demonstrates inhibitory and excitatory effects as observed in a neuronal network cultivated on a multielectrode array (MEA) neurochip. 1 Background 1.1 Experimental background A mouse has four millions of cortical neurons [1]. In an in-vitro experiment approximately 10.000 neurons of the frontal cortex of embryonic mice(More)