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This paper is a review of experiments, performed in our laboratory during the past 20 years, designed to analyse the significance of different components of random variability in quantitative traits in laboratory rats and mice. Reduction of genetic variability by using inbred strains and reduction of environmental variability by highly standardized(More)
The functions of the rat forestomach and upper digestive tract were studied. The pH values, alpha-amylase activity, quantitative estimates of microorganisms, and emptying rates were higher in the forestomach than in the glandular stomach. Rats with surgically removed forestomachs lived without complications for more than 1 yr. Their alimentary hyperglycemia(More)
Adult male mice (DBA/2J) siblings were housed three per cage for 6 wk, either in standard cages (SC) or in enriched cages (EC). Both attacks among group members and attacks against strange intruders were monitored once a week within each of 22 experimental groups. According to its attacking behavior, each mouse was categorized into one of three dominance(More)
The effect of intraluminal challenge on rat colonic mucin producing cells and the amount and composition of released mucins was investigated. Germfree rats (GF) were maintained on a commercial high fiber (HF) diet (37% of undigestable fiber, Altromin 1640 p), in order to increase volume, dry weight and abrasive effect of the ingesta. GF control rats were(More)
The activation of different neuroendocrine subsystems depends on the individual perception and coping with the challenging situation, the formulation of these relations by J.P. Henry represents a most useful concept also for the assessment of welfare consequences of particular caging variables. We investigated effects of cage enrichment on behaviour and(More)
The relative kidney weight (1.44% greater than 1.15% greater than 1.07%) and the GFR (44 greater than 39 greater than 35 ml/min . m2) are higher in adult males than in adult females or in orchiectomized males. In contrast, GFR based on kidney weight is smallest in healthy males (1.02 less than 1.22; 1.22 ml/min . g). Only the cortex tissue seems to be(More)
Secreting lubricating mucins, colonic crypt goblet cells, contribute to the intestinal protection against mechanical challenge. After feeding germ-free (GF) and specific pathogen-free (SPF) AS/Ztm rats for 6 weeks, the proliferative response of colonic goblet to a commercial bulky diet (37.1% fiber) was compared to that of a standard diet. (4.4% fiber). An(More)