Kerstin Dallmann

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The proteome of RCC was analyzed by 2D PAGE to search for tumor-associated proteins. Agmatinase, which hydrolyzes agmatine to putrescine and urea, was identified by mass spectrometry and database searches and shown to be downregulated in tumor cells. Additionally, RT-PCR and Northern blot analyses demonstrated a clearly decreased amount of agmatinase mRNA(More)
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