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Major depressive disorder (MDD) is a common, clinically heterogeneous disorder often found comorbid with other disorders. We studied recurrent, early-onset MDD (MDD-RE) and anxiety disorders in combination to define powerful phenotypes for genetic study. We used 87 large, extended Utah pedigrees to investigate linkage to 3 phenotypes: "MDD-RE;" "MDD-RE or(More)
OBJECT This study was conducted to investigate the familial and genetic contribution to intracranial, abdominal aortic, and all other types of aneurysms, and to define familial relationships among patients who present with the different aneurysm types. METHODS The authors used a unique Utah resource to perform population-based analysis of the familial(More)
OBJECTIVE Electronically linked datasets have become an important part of clinical research. Information from multiple sources can be used to identify comorbid conditions and patient outcomes, measure use of healthcare services, and enrich demographic and clinical variables of interest. Innovative approaches for creating research infrastructure beyond a(More)
Background The Utah Population Database (UPDB) is a shared research resource of the University of Utah. It combines Utah genealogies dating back to the 1700s with data from statewide resources, including a cancer registry, hospital claims, as well as birth and death certificates. A project completed in 2008 linked the UPDB to patient demographic records(More)
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