Kerri L Dietrich

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Two cDNA clones encoding distinct members of the corticotropin-releasing factor (CRF) receptor family have been isolated from Xenopus laevis with PCR-based approaches. The first full-length cDNA amplified from Xenopus brain encoded a 415-amino acid protein with approximately 80% identity to mammalian CRF receptor type 1 (CRF-R1). The second full-length cDNA(More)
The present experiment examined the effects of unilateral or bilateral locus coeruleus lesions on general activity, acquisition of a non-monotonic serial pattern (14-0-3-7 food pellets, respectively), and response learning acquisition in a Greek cross version of the Morris water maze. Sham-operated control rats were capable of tracking the elements of the(More)
Posterior parietal, hippocampal, or sham-lesioned rats were tested for the acquisition of a non-monotonic serial learning task. The performance of control rats and those with a posterior parietal lesion was similar, while those with hippocampal damage demonstrated a working memory deficit. The results are integrated with contemporary conceptualizations of(More)
Past research suggests that public support for the use of animal models as means to improve the human condition is present but many individuals have expressed ambivalence. In the present study, various sectors of the academic community (students and faculty) as well as the general population, were surveyed to assess their positions on the need for, and(More)
Foxy or Methoxy Foxy (5-methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is rapidly gaining popularity among recreational users as a hallucinogenic "designer drug." Unfortunately, much remain unknown about the consequences of its use on neuropsychological development or behavior. During one of two adolescent periods, the rats were given(More)
Piperoxane is an alpha 2-noradrenergic antagonist with demonstrated excitatory effects on neurons in the locus coeruleus, causing a corresponding increase in norepinephrine in many forebrain areas. 16 male Fischer-344 rats approximately 16 months of age were injected with 3 mg/kg of piperoxane or .09% saline. The piperoxane-treated rats lived an average of(More)
The acquisition of a serial pattern was assessed in young (3-month), senescent (24-month), and hippocampal-lesioned rats. All animals were trained for 25 days on a four-element, nonmonotonic pattern consisting of 14, 0, 3, and 7 food pellets, respectively. Young rats were capable of distinguishing among the elements of the series, with the exception of the(More)
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