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Estrogens are defined by their ability to induce the proliferation of cells of the female genital tract. The wide chemical diversity of estrogenic compounds precludes an accurate prediction of estrogenic activity on the basis of chemical structure. Rodent bioassays are not suited for the large-scale screening of chemicals before their release into the(More)
Estrogenic pesticides such as DDT and chlordecone generate deleterious reproductive effects. An "in culture" bioassay was used to assess the estrogenicity of several pesticides. The E-screen test uses human breast estrogen-sensitive MCF7 cells and compares the cell yield achieved after 6 days of culture in medium supplemented with 5% charcoal-dextran(More)
BACKGROUND Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functions. All these cell types have been(More)
Let X(t) (05 t < 00) be the Brownian motion process. Concerning the uniform continuity of X(t), there exists P. Levy's result. Before stating his result, let us define the concept of upper class and lower class with regard to the uniform continuity of X(t) (0 2 ts 1). If there exists a positive number E such that 1 t'-t[ 5 E implies the relation (1)(More)
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