Keri S Chaney

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Cutaneous T cell lymphoma (CTCL) is a cancer of skin-homing T cells with variants that include leukemic CTCL (L-CTCL), a malignancy of central memory T cells (T(CM)), and mycosis fungoides (MF), a malignancy of skin resident effector memory T cells (T(EM)). We report that low-dose alemtuzumab (αCD52) effectively treated patients with refractory L-CTCL but(More)
BACKGROUND Allergic contact dermatitis in young children may be an under-recognized cause of perineal dermatitis. The diapered infant skin is uniquely susceptible to allergic contact dermatitis because of more permeable neonatal skin, a moist environment, frequent contact with irritants and resultant skin barrier breakdown, and exposure to topical products(More)
Mycosis fungoides (MF) is characterized by skin accumulation of CCR4+CCR7- effector memory T cells; however the mechanism for their recruitment is not clearly identified. Thymic Stromal Lymphopoietin (TSLP) is a keratinocyte-derived cytokine that triggers Th2 immunity and is associated with T cell recruitment to the skin in atopic dermatitis. Interleukin-16(More)
Sézary syndrome is one of the most common forms of cutaneous T cell lymphoma (CTCL). It is characterized by skin infiltration of malignant T cells. We examined interleukin-16, a potent T cell chemoattractant and cell-cycle regulator, as a prospective marker of disease onset and stage. The correlation of total intracellular interleukin-16 and surface CD26(More)
BACKGROUND Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed. OBJECTIVE The aim was to quantify patch test results from providers evaluating US children. METHODS The study is a retrospective analysis of deidentified patch test(More)
BACKGROUND The use of many of the standard skin-directed mycosis fungoides (MF) therapies on facial skin may be limited by site-specific increased risks of side effects, excessive inflammation, and ocular toxicity. OBJECTIVE Our study aimed to describe the levels of erythema, scale, and induration of facial lesions in MF before and after low-dose(More)
Mycosis fungoides (MF) is a cutaneous T-cell lymphoma composed of epidermotropic atypical effector memory T lymphocytes (1). MF patients can suffer from debilitating pruritus (1). Clinical and experimental observations implicate signaling by the neurokinin-1 receptor (NK1R) and its highest affinity ligand, substance P (SP), in the epidermotropism and(More)
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