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Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in whichExpand
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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Single-cell RNA sequencing identifies a common origin for specific types of human glioma brain tumors. Effects of the tumor microenvironment Glioma brain tumors that carry mutant copies of the IDHExpand
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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
Treatment of cancer has been revolutionized by immune checkpoint blockade therapies. Despite the high rate of response in advanced melanoma, the majority of patients succumb to disease. To identifyExpand
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Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model
Motivation: The availability of modern sequencing techniques has led to a rapid increase in the amount of reconstructed metabolic networks. Using these models as a platform for the analysis of highExpand
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Resistance to checkpoint blockade therapy through inactivation of antigen presentation
Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance toExpand
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RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
Somatic mosaicism in normal tissues Somatic cells can accumulate mutations over the course of an individual's lifetime. This generates cells that differ genetically at specific loci within theExpand
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Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
The cellular composition of H3K27M gliomas Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options forExpand
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Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
Utilizing molecular data to derive functional physiological models tailored for specific cancer cells can facilitate the use of individually tailored therapies. To this end we present an approachExpand
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Diversion of aspartate in ASS1-deficient tumors fosters de novo pyrimidine synthesis
Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammoniaExpand
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Modeling cancer metabolism on a genome scale
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolicExpand
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