Keqing Zhao

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Orai1 is an essential pore-forming subunit of the Ca2+ release-activated Ca2+ channels and plays a key role in the store-operated Ca2+ entry. However, little is known about the function of this pathway in allergic airway diseases. In this study, we evaluated Orai1 expression in normal and allergic rhinitis (AR) mice airway and spleen. AR models were(More)
Mesenchymal stem cells (MSCs) have arisen the attention to be a new attractive therapeutic tool treating autoimmune diseases such as allergic rhinitis (AR). AR is a chronic reversible allergic inflammation caused by the excessive activation of T-helper 2 (Th2) cells. Recently, MSCs have been proposed as a new therapy of AR as it can suppress some cytokines(More)
Although CD23-dependent transcytosis of IgE and IgE-derived immune complexes across respiratory epithelial cells is likely to play a pivotal role in the initiation and development of airway allergic inflammation, there is currently a lack of physiological support for this phenomena to suggest that the targeting of CD23 could be used as a means of(More)
OBJECTIVE Orai1 is the pore-forming subunit of the Ca(2+) release-activated Ca(2+) channels and plays a key role in the store-operated Ca(2+) entry. However, little is known about the function of this pathway in allergic rhinitis (AR). In this study, we examined whether the intervention of Orai1 pathway was capable of controlling IgE-mediated allergic(More)
Two-component supramolecular networks have been constructed with a symmetric triphenylene derivative with three carboxyl groups (sym-TTT) and melamine. Two kinds of hydrogen bonds with different strength are involved in the multi-component self-assembly, one is H-bond between carboxyl group of sym-TTT and melamine, the other is intermolecular H-bond between(More)
The underlying mechanisms of mesenchymal stromal cells (MSCs) on immune modulation to treat allergic diseases remain unclear. Here, we showed that the suppressor of cytokine signaling 3 (SOCS3) is an important immune modulator expressed by MSCs, which is significantly increased by interferon-γ (IFN-γ). In addition, we observed that SOCS3 is a crucial(More)
OBJECTIVE To evaluate the photodynamic therapy (PDT) against multi-antibiotic-resistant Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S.epidermidis) obtained from patients with chronic rhinosinusitis (CRS). METHODS Forty-five CRS patients who had been given medical treatment but still needed endoscopic surgery were included in this(More)
A new discotic liquid crystal template has been found and the host-guest architecture structures on highly oriented pyrolytic graphite (HOPG) surface have been identified with scanning tunneling microscope (STM). This discotic liquid crystal molecule can function as a new molecular template for distribution and dispersion of organic molecules. The present(More)
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