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The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here, we describe a previously unknown posttranslational modification of the DNA-binding domain of p53. This modification, acetylation of lysine 120 (K120), occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases hMOF and TIP60. Mutation of(More)
The system partitioning problem in a partitionable mesh connected system (PMCS) is addressed. A two dimensional buddy system (2DBS) is proposed as a partitioning scheme for dynamic resource allocation in a PMCS. Allocation and reclamation algorithms and the method for locating buddies are designed. Internal fragmentation of our proposed 2DBS under various(More)
Low levels of histone covalent modifications are associated with gene silencing at telomeres and other regions in the yeast S. cerevisiae. Although the histone deacetylase Sir2 maintains low acetylation, mechanisms responsible for low H2B ubiquitylation and low H3 methylation are unknown. Here, we show that the ubiquitin protease Ubp10 targets H2B for(More)
We present efficient parallel matrix multiplication algorithms for linear arrays with reconfigurable pipelined bus systems (LARPBS). Such systems are able to support a large volume of parallel communication of various patterns in constant time. An LARPBS can also be reconfigured into many independent subsystems and, thus, is able to support parallel(More)
In this paper, we address the job scheduling problem in a partitionable mesh-connected system when jobs require square meshes and the system is a square mesh of size a power of two. We present a heuristic algorithm of time complexity O(n(log n + log p))where n is the number of jobs to be scheduled and p is the size of the system. The algorithm adopts the(More)
Energy-efficient scheduling of sequential tasks with precedence constraints on multiprocessor computers with dynamically variable voltage and speed is investigated as combinatorial optimization problems. In particular, the problem of minimizing schedule length with energy consumption constraint and the problem of minimizing energy consumption with schedule(More)