Kento Kawamura

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The growth of Brevibacterium flavum FA1-30, a L-lysine-producing mutant strain with an aspartokinase desensitized to feedback inhibition, was almost completely inhibited by a-ketobutyrate (αKB) at concentrations more than 4 mg/ml. Aspartic acid hydroxamate (Asphx) did not inhibit the growth at a concentration up to 6 mg/ml, but slightly stimulated the αKB(More)
Drug resistance often critically limits the efficacy of molecular targeted drugs. Although pharmacological inhibition of phosphatidylinositol 3-kinase (PI3K) is an attractive therapeutic strategy for cancer therapy, molecular determinants for efficacy of PI3K inhibitors (PI3Kis) remain unclear. We previously identified that overexpression of insulin-like(More)
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