Kentaro Miura

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Impairment of circadian rhythmicity in the elderly has been suggested to cause age-associated diseases such as atherosclerosis and hypertension. Endothelium-derived nitric oxide (NO) is a critical regulator of cardiovascular homeostasis, but its production declines with aging, thereby inducing vascular dysfunction. We show here that impaired circadian(More)
Juxtacortical chondrosarcoma developing on the surface of a bone is quite rare. We report a case of juxtacortical chondrosarcoma arising on the fourth rib of a 76-year-old man. Intraregional tumor resection was performed, but local recurrence was detected after 6 months. The patient underwent wide resection including the ribs, and reconstruction of the(More)
Threshold voltage shifts of amorphous In-Ga-Zn-Oxide (a-InGaZnO) TFTs on plastic substrates against bias-temperature stress were reduced below 0.03 V, equivalent to those on glass substrates. We have developed 10.2-inch WUXGA (1920×1200) flexible bottom-emission active-matrix organic light-emitting diode (AMOLED) driven by a-InGaZnO TFTs fabricated(More)
Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant disease caused by mutations of germline folliculin (FCLN) mapped in the chromosome 17p11.2 region. BHD commonly accompanies renal tumors, fibrofolliculomas, multiple pulmonary cysts, and spontaneous pneumothorax. We report a case of a young Japanese woman in whom asymptomatic bilateral pneumothorax was(More)
We report a case of pleomorphic carcinoma with exon 18 mutation (G719X) of the epidermal growth factor receptor (EGFR), which showed good response to afatinib and resulted in successful resection. To our knowledge, this is the first report on the use of afatinib for pleomorphic carcinoma followed by the surgical resection. The patient was a 59-year-old(More)
There have been great progresses in our knowledge of patho-physiology on various cardiovascular diseases, which enabled us to develop the field of regenerative medicine for previously untreatable patients. Among several strategies in cardiovascular regenerative medicine, cell transplantation is one of the best studied and the best clinically practiced. In(More)
BACKGROUND It remains unclear whether the preoperative pulmonary function parameters and prognostic indices that are indicative of nutritional and immunological status are associated with prognosis in lung cancer patients with combined pulmonary fibrosis and emphysema (CPFE) who have undergone surgery. OBJECTIVE The aim of this study is to identify(More)
In 2011,mucinous bronchioloalveolar carcinoma was reclassified as invasive mucinous adenocarcinoma, mucinous adenocarcinoma in situ,and mucinous minimally invasive adenocarcinoma.A part of the invasive mucinous adenocarcinoma of the lung differentiates to gastric mucous cells, and we term this type of carcinoma gastric-like invasive mucinous(More)
OBJECTIVES Cases of lung cancer with pure ground-glass nodules (GGNs) have been detected with increasing frequency since the advent of computed tomography (CT), and growth is sometimes noted during follow-up. The objective of this study was to evaluate the potential predictive factors for pure GGN growth. MATERIALS AND METHODS We retrospectively examined(More)
We report a case of hilar lymph node metastasis of amelanotic malignant melanoma of unknown origin. A left pulmonary nodule was detected during a check-up in a 58-year old woman. Chest computed tomography indicated a large left hilar mass located between the upper and lower lobes. She underwent left pneumonectomy with mediastinal lymph node dissection, and(More)