Kentaro Mikami

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Caloric restriction (CR) slows the aging process and extends longevity, but the exact underlying mechanisms remain debatable. It has recently been suggested that the beneficial action of CR may be mediated in part by adipose tissue remodeling. Mammals have two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT). In this study,(More)
Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that autophagosome formation was accelerated, but autophagic(More)
1.31) were randomized to 1 of the 4 treatment groups. MF/F increased the time to first asthma deterioration thus decreasing the proportion of subjects experiencing asthma deterioration during the study (MF/F ¼ Low rates of AEs were observed and were similar between treatment arms. Conclusions: In asthmatics previously treated with low-dose ICS with or(More)
linearized ovomucoid increases IgE-reactivity in patients with persistent egg-allergy in vitro and in skin prick tests. Our data provide evidence that reduction is a novel principle which contributes to the allergenicity of food. This may be relevant for new allergies to modern processed food. Background: Classical allergen-specific immunotherapy (SIT),(More)
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