Kentaro Mikami

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Caloric restriction (CR) slows the aging process and extends longevity, but the exact underlying mechanisms remain debatable. It has recently been suggested that the beneficial action of CR may be mediated in part by adipose tissue remodeling. Mammals have two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT). In this study,(More)
Autophagy is induced by several kinds of stress, including oxidative, genotoxic, endoplasmic reticulum and nutrient stresses. The tumor suppressor p53, which is a stress sensor, plays a critical role in the regulation of autophagy. Although p53 is required for starvation (nutrient deficient stress)-induced autophagy, it is still not clear whether p53 is(More)
The p53 protein is known as a guardian of the genome and is involved in energy metabolism. Since the metabolic system is uniquely regulated in each tissue, we have anticipated that p53 also would play differential roles in each tissue. In this study, we focused on the functions of p53 in white adipose tissue (adipocytes) and skeletal muscle (myotubes),(More)
It is known that a Poisson structure with constant rank on a manifold, called a regular Poisson structure, defines the symplectic foliation on the manifold. For each transversely oriented foliation, we have the famous Godbillon-Vey characteristic class. When the symplectic foliations of regular Poisson structures are transversely oriented, they have the(More)
Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that autophagosome formation was accelerated, but autophagic(More)
Coordination reaction between linolenic-acid-hydroperoxide (LHPO) and chloro(5, 10, 15, 20-tetraphenyl)-porphyrinato iron (III), Fe(III)TPPCl, was investigated by means of ESR. ESR spectra of the ferric low-spin complex (g1 = 2.336, g2 = 2.174 and g3 = 1.929) was recorded for the mixture prepared by mixing Fe(III)TPPCl and LHPO at -78 degrees C in the(More)
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