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  • Hiroko Izumi-Nakaseko, Yasunari Kanda, +6 authors Atsushi Sugiyama
  • Biology, Medicine
  • Journal of pharmacological sciences
  • 2017 (First Published: 1 September 2017)
  • Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been used in many studies to assess proarrhythmic risks of chemical compounds. In those studies, field potential durationsContinue Reading
  • Yuji Nakamura, Rieko Sasaki, +7 authors Atsushi Sugiyama
  • Biology, Medicine
  • Journal of pharmacological sciences
  • 2016 (First Published: 1 May 2016)
  • We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir inContinue Reading
  • Yukihiro Yagi, Yuji Nakamura, +9 authors Atsushi Sugiyama
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 2014 (First Published: 1 November 2014)
  • Fingolimod, a sphingosine 1-phosphate (S1P) receptor subtype 1, 3, 4 and 5 modulator, has been used for the treatment of patients with relapsing forms of multiple sclerosis, but atrioventricularContinue Reading