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Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spine morphology, such as filopodia-like(More)
Morphological plasticity of dendritic spines and synapses is thought to be crucial for their physiological functions. Here we show that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. In the absence of alpha N-catenin, spine(More)
A synapse is the connection between neurons that joins an axon of one neuron to the dendrite of another. One class of synapses is formed at the contact point between an axon and a small protrusion from a dendrite, called a dendritic spine. These spines are motile and deformable, which indicates that synaptic functions are controlled, at least in part, by(More)
The canonical Wnt-beta-catenin signaling pathway is important for a variety of developmental phenomena as well as for carcinogenesis. Here, we show that, in hippocampal neurons, NMDA-receptor-dependent activation of calpain induced the cleavage of beta-catenin at the N terminus, generating stable, truncated forms. These beta-catenin fragments accumulated in(More)
An intracellular horseradish peroxidase study combined with immunoperoxidase techniques was carried out on hippocampal CA1 pyramidal neurons in the rat. Most axon branches originating from a single CA1 pyramidal neuron ran caudally and terminated in the subiculum. The individual axon branches of the single pyramidal neurons bifurcated repeatedly in the(More)
The mobility of restriction-modification (RM) gene complexes and their association with genome rearrangements is a subject of active investigation. Here we conducted systematic genome comparisons and genome context analysis on fully sequenced prokaryotic genomes to detect RM-linked genome rearrangements. RM genes were frequently found to be linked to(More)
Neurons can change their gene expression patterns according to the inputs they have received. This activity-dependent gene regulation mechanism plays an important role in the formation of neural circuits during development. Further, by regulating the synaptic plasticity, this mechanism may function as an essential one for each organism to adapt flexibly to(More)
Keratan sulfate proteoglycans (KSPGs) and chondroitin sulfate proteoglycans (CSPGs) consist of a protein core with covalently attached glycosaminoglycan side chain. Although CSPGs are known to regulate the end of the critical period, the role of KSPGs in brain development remains unclear. Young male zebra finches memorise song templates during development.(More)
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