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Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.
Somatic mutation analysis is a standard practice in the study of human cancers to identify mutations that cause therapeutic sensitization and resistance. We performed comprehensive genomic analysesExpand
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Histamine Is a Potent Inducer of IL-18 and IFN-γ in Human Peripheral Blood Mononuclear Cells
Histamine (10−7 to 10−4 M) concentration-dependently stimulated the production of IL-18 and IFN-γ and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine in the same concentrationExpand
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CRKL oncogene is downregulated by p53 through miR-200s
Tumor suppressive miRNAs that target oncogenes are frequently downregulated in cancers, and this downregulation leads to oncogene pathway activation. Thus, tumor suppressive miRNAs and their targetExpand
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Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma
Somatic mutation analysis is a standard of practice for human cancers to identify therapeutic sensitization and resistance mutations. We performed a multigene sequencing screen to explore mutationalExpand
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Rydberg transitions as a probe for structural changes and phase transition at polymer surfaces: an ATR-FUV-DUV and quantum chemical study of poly(3-hydroxybutyrate) and its nanocomposite with
We investigated the surface (<50 nm) of poly(3-hydroxybutyrate) (PHB) and its nanocomposite with graphene by attenuated total reflection far- and deep-ultraviolet (ATR-FUV-DUV; 145-300 nm; 8.55-4.13Expand
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A Case Report of .ALPHA.-fetoprotein Producing Gastric Adenocarcinoma with Portal Venous Thrombosis.
門脈本幹内に充満する腫瘍塞栓を形成したα-fetoprotein (以下, AFPと略記) 産生進行胃癌の切除例を経験した.症例は, 72歳の男性で胃角部から前庭部の小轡側を中心としたBorrmann 3型胃癌があり, 術前血清AFP値が20,780ng/mlと異常高値を示した.開腹所見は, 胃癌取扱い規約によるとT3, N3, P0, H0, M0,Expand
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Clinical Value of Neopterin In Infectious Complications
Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation, mainly by gamma-interferon by activated TExpand
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[CR obtained by CPT-11 and CDDP combination-therapy in a small-cell lung-cancer patient through effective pharmaceutical care].
We encountered a 64-year-old UGT1A1*28 heterotype patient who received CPT-11 and CDDP chemotherapy for Stage III A small-cell lung-cancer and developed grade 4 neutropenia as assessed by CTCAE v3.0Expand