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BACKGROUND Since the start of the 2009 influenza A pandemic (H1N1pdm), the World Health Organization and its member states have gathered information to characterize the clinical severity of H1N1pdm infection and to assist policy makers to determine risk groups for targeted control measures. METHODS AND FINDINGS Data were collected on approximately 70,000… (More)
A fatal case of severe fever with thrombocytopenia syndrome was reported in Japan in 2013. The ensuing process of public communication offers lessons on how to balance public health needs with patient privacy and highlights the importance of multilateral collaborations between scientific and political communities.
Communicated by Masayuki Saijo Middle East Respiratory Syndrome (MERS) is an emerging respiratory disease caused by a newly identified coronavirus the MERS coronavirus (MERS-CoV) (1–3). The outbreak has mainly remained in Saudi Ara-bia since 2012, with 1,106 laboratory confirmed cases to date, which have resulted in 421 Initially, bats were considered the… (More)
For recordings from Purkinje cells, cerebellar slices were prepared as described (Hildebrand et al., 2009). Briefly, mice were anesthetized and decapitated, the cerebellar vermis was dissected in ice-cold bicarbonate-buffered saline (BBS) containing
Ghrelin is a growth hormone-releasing peptide that also displays orexigenic activity. Since serine-3 acylation with octanoylate (octanoylation) is essential for the orexigenic activity of ghrelin, suppression of octanoylation could lead to amelioration or prevention of obesity. To enable the exploration of inhibitors of octanoylated ghrelin production, we… (More)
Fecal egg count reduction tests (FECRT) and larval migration inhibition tests (LMIT) were conducted to assess the efficacy of ivermectin (IVM) against gastrointestinal nematodes on 2 cattle farms in northern Japan in 2009 and 2010. Twelve to 20 calves on each farm were treated topically with 0.5 mg IVM/kg 2 (Farm 2) or 4 times (Farm 1) during the grazing… (More)